The support services for clinical research are described together because they share resourcesand personnel and operate in an integrated manner to achieve common objectives.Clinical research at CHOP will be organized largely through the Clinical Core. This Core provides.the infrastructure for patient management enabling the recruitment of subjects for specific projectsin particular, the inter-Center collaborative clinical studies. The Clinical Core is staffed byhematologists, research nurses, social worker, psychologist, psychiatrist, genetic counselor, datacoordinator, and administrative support staff. They will be responsible for education, recruitment,and enrollment of study subjects. In addition, they will coordinate the scheduling of subject visits,clinical monitoring of study subjects, data collection, communication with the Statistical and DataManagement Center, and all other required procedures to enable the smooth conduct of approvedclinical studies.Several members of the Clinical Core staff will also serve the patient care Services Core of theCenter. These activities will include the Educational, Diagnostic, counseling, and CommunityOutreach programs of the Center. In many cases these services will be performed in collaborationwith other services available in the home institution or in the community. The Center will continueto offer its regional and national Professional (Continuing) Education program at the major nationalsickle cell conferences.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54HL070596-01
Application #
7527836
Study Section
Special Emphasis Panel (ZHL1-CSR-F (S1))
Project Start
2003-07-22
Project End
2008-03-31
Budget Start
2003-07-22
Budget End
2004-03-31
Support Year
1
Fiscal Year
2003
Total Cost
$11,050
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Dougherty, Kelly A; Schall, Joan I; Kawchak, Deborah A et al. (2012) No improvement in suboptimal vitamin A status with a randomized, double-blind, placebo-controlled trial of vitamin A supplementation in children with sickle cell disease. Am J Clin Nutr 96:932-40
Dougherty, Kelly A; Schall, Joan I; Rovner, Alisha J et al. (2011) Attenuated maximal muscle strength and peak power in children with sickle cell disease. J Pediatr Hematol Oncol 33:93-7
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Peranteau, William H; Heaton, Todd E; Gu, Yu-Chen et al. (2009) Haploidentical in utero hematopoietic cell transplantation improves phenotype and can induce tolerance for postnatal same-donor transplants in the canine leukocyte adhesion deficiency model. Biol Blood Marrow Transplant 15:293-305
Adachi, Kazuhiko; Ding, Min; Asakura, Toshio et al. (2009) Relationship between beta4 hydrogen bond and beta6 hydrophobic interactions during aggregate, fiber or crystal formation in oversaturated solutions of hemoglobin A and S. Arch Biochem Biophys 481:137-44
Rovner, Alisha J; Stallings, Virginia A; Kawchak, Deborah A et al. (2008) High risk of vitamin D deficiency in children with sickle cell disease. J Am Diet Assoc 108:1512-6
Adachi, Kazuhiko; Ding, Min; Surrey, Saul (2008) Role of the beta4Thr-beta73Asp hydrogen bond in HbS polymer and domain formation from multinucleate-containing clusters. Biochemistry 47:5441-9

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