The suprachiasmatic nucleus (SCN) of the hypothalamus is considered to be the circadian oscillator (clock) and is entrained by the environmental light/dark cycle. The SCN influences various physiological and behavioral activities. Locomotor activity exhibit a clearly defined circadian rhythmicity. The neuroanatomical substrates subserving the circadian locomotor activity are unknown. Bilateral lesioning of the SCN renders the locomotor activity arrhythmic. Transplantation of hypothalamic tissue containing the SCN into the third ventricle restored circadian locomotor activity in SCN lesioned animals. We hypothesize that the circadian entrainment of locomotor activity by the SCN is mediated via efferent projection fibers to specific neuronal population(s) within the motor system. The proposed three year project is designed to identify the neuroanatomical substrates that communicates SCN generated circadian signals within the motor system.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Pulliam, John V K; Xu, Zhenfeng; Ford, Gregory D et al. (2013) Computational identification of conserved transcription factor binding sites upstream of genes induced in rat brain by transient focal ischemic stroke. Brain Res 1495:76-85
Li, Yonggang; Lein, Pamela J; Liu, Cuimei et al. (2012) Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury. Toxicol Appl Pharmacol 262:194-204
Rodriguez-Mercado, Rafael; Ford, Gregory D; Xu, Zhenfeng et al. (2012) Acute neuronal injury and blood genomic profiles in a nonhuman primate model for ischemic stroke. Comp Med 62:427-38
Mong, Jessica A; Baker, Fiona C; Mahoney, Megan M et al. (2011) Sleep, rhythms, and the endocrine brain: influence of sex and gonadal hormones. J Neurosci 31:16107-16
Guo, Qingmin; Wang, Guangming; Namura, Shobu (2010) Fenofibrate improves cerebral blood flow after middle cerebral artery occlusion in mice. J Cereb Blood Flow Metab 30:70-8
Davidson, Alec J; Castanon-Cervantes, Oscar; Leise, Tanya L et al. (2009) Visualizing jet lag in the mouse suprachiasmatic nucleus and peripheral circadian timing system. Eur J Neurosci 29:171-80
Wang, Guangming; Guo, Qingmin; Hossain, Mohammed et al. (2009) Bone marrow-derived cells are the major source of MMP-9 contributing to blood-brain barrier dysfunction and infarct formation after ischemic stroke in mice. Brain Res 1294:183-92
Paul, Ketema N; Laposky, Aaron D; Turek, Fred W (2009) Reproductive hormone replacement alters sleep in mice. Neurosci Lett 463:239-43
Guo, Qingmin; Wang, Guangming; Liu, Xiaowei et al. (2009) Effects of gemfibrozil on outcome after permanent middle cerebral artery occlusion in mice. Brain Res 1279:121-30
Fukuhara, Chiaki; Tosini, Gianluca (2008) Analysis of daily and circadian gene expression in the rat pineal gland. Neurosci Res 60:192-8

Showing the most recent 10 out of 29 publications