Abstract

Since cembranoids are not commercially available, it is necessary to obtain them from their natural sources: soft corals found in the tropical seas around Puerto Rico, or from tobacco leaves grown on the island. The Natural Products Core will provide the cembranoids needed in the Project 1 and Project 2 from SNRP-1, which will continue to be a part of this program for one year in order to obtain additional results needed for their RO1 grant proposals. This core will organize diving expeditions for collection of specimens, will isolate the compounds to high purity and determine their molecular structures.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54NS039408-06
Application #
7120463
Study Section
Special Emphasis Panel (ZNS1-SRB-H (16))
Project Start
2005-09-07
Project End
2006-08-31
Budget Start
2005-09-07
Budget End
2006-08-31
Support Year
6
Fiscal Year
2005
Total Cost
$79,349
Indirect Cost

  Institution

Name
Universidad Central Del Caribe
Department
Type
DUNS #
090534694
City
Bayamon
State
PR
Country
United States
Zip Code
00960

  Publications

Budworth, Helen; Harris, Faye R; Williams, Paul et al. (2015) Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease. PLoS Genet 11:e1005267
Martins, Antonio H; Hu, Jing; Xu, Zhenfeng et al. (2015) Neuroprotective activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in rodent models of brain ischemia. Neuroscience 291:250-259
Bykhovskaia, Maria; Jagota, Anand; Gonzalez, Agustin et al. (2013) Interaction of the complexin accessory helix with the C-terminus of the SNARE complex: molecular-dynamics model of the fusion clamp. Biophys J 105:679-90
Ferchmin, P A; Pérez, Dinely; Castro Alvarez, William et al. (2013) ?-Aminobutyric acid type A receptor inhibition triggers a nicotinic neuroprotective mechanism. J Neurosci Res 91:416-25
Torres-Rivera, W; Pérez, D; Park, K-Y et al. (2013) Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage. Neuroscience 247:273-9
Eterovi?, Vesna A; Del Valle-Rodriguez, Angelie; Pérez, Dinely et al. (2013) Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: preliminary structure-activity relationship and pharmacophore modeling. Bioorg Med Chem 21:4678-86
Maldonado, Carolina; Alicea, Daniel; Gonzalez, Maryvi et al. (2013) Adar is essential for optimal presynaptic function. Mol Cell Neurosci 52:173-80
Rodriguez-Mercado, Rafael; Ford, Gregory D; Xu, Zhenfeng et al. (2012) Acute neuronal injury and blood genomic profiles in a nonhuman primate model for ischemic stroke. Comp Med 62:427-38
Martins, Antonio H; Alves, Janaina M; Perez, Dinely et al. (2012) Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of kinin-B1 receptor agonists. PLoS One 7:e30755
Long, Rong; Hui, Chung-Yuen; Jagota, Anand et al. (2012) Adhesion energy can regulate vesicle fusion and stabilize partially fused states. J R Soc Interface 9:1555-67

Showing the most recent 10 out of 54 publications