OVERVIEW The ongoing major objective of our University of Rochester Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center (MDCRC) is to integrate basic, translational, and clinical research on the two most common forms of adult muscular dystrophy, myotonic dystrophy (DM1 &DM2) and facioscapulohumeral muscular dystrophy (FSHD). To pursue this objective, in our currently funded Wellstone Center research, investigators have carried out three scientific projects and have established two scientific core facilities (Imaging Core &Repository Core) as well as having developed a smoothly operating Administrative Core.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54NS048843-10
Application #
8381147
Study Section
Special Emphasis Panel (ZAR1-KM-J)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
10
Fiscal Year
2012
Total Cost
$130,511
Indirect Cost
$45,764
Name
University of Rochester
Department
Type
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
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Gadalla, S M; Hilbert, J E; Martens, W B et al. (2017) Pigmentation phenotype, photosensitivity and skin neoplasms in patients with myotonic dystrophy. Eur J Neurol 24:713-718
Jauvin, Dominic; Chr├ętien, Jessina; Pandey, Sanjay K et al. (2017) Targeting DMPK with Antisense Oligonucleotide Improves Muscle Strength in Myotonic Dystrophy Type 1 Mice. Mol Ther Nucleic Acids 7:465-474
Skov, Martin; Dirksen, Robert T (2017) Trojan triplets: RNA-based pathomechanisms for muscle dysfunction in Huntington's disease. J Gen Physiol 149:49-53
Pinto, Belinda S; Saxena, Tanvi; Oliveira, Ruan et al. (2017) Impeding Transcription of Expanded Microsatellite Repeats by Deactivated Cas9. Mol Cell 68:479-490.e5

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