Abstract

The goal of the Pilot/Feasibility Projects Core (PFP) is to fund promising projects that take advantage of new clinical research opportunities in HHT, CCM, SWS, or other rare diseases thematically related to the BVMC. These projects will demonstrate feasibility and generate proof-of-concept data for future grant funding, and are aimed at diagnosis or management/treatment of BVMC related diseases. They will have potential for high impact one or more of the BVMC diseases, with particular emphasis on clinical trial readiness. We will support a minimum of 3 or a maximum of 5 pilot projects (one per year).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54NS065705-11
Application #
9804275
Study Section
Special Emphasis Panel (ZTR1)
Project Start
Project End
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
11
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118

  Publications

Wellman, Rebecca J; Cho, Su Bin; Singh, Pratibha et al. (2018) G?q and hyper-phosphorylated ERK expression in Sturge-Weber syndrome leptomeningeal blood vessel endothelial cells. Vasc Med :1358863X18786068
Morrison, Melanie A; Payabvash, Seyedmehdi; Chen, Yicheng et al. (2018) A user-guided tool for semi-automated cerebral microbleed detection and volume segmentation: Evaluating vascular injury and data labelling for machine learning. Neuroimage Clin 20:498-505
Walcott, Brian P; Winkler, Ethan A; Zhou, Sirui et al. (2018) Identification of a rare BMP pathway mutation in a non-syndromic human brain arteriovenous malformation via exome sequencing. Hum Genome Var 5:18001
Pawlikowska, Ludmila; Nelson, Jeffrey; Guo, Diana E et al. (2018) Association of common candidate variants with vascular malformations and intracranial hemorrhage in hereditary hemorrhagic telangiectasia. Mol Genet Genomic Med 6:350-356
De la Torre, Alejandro J; Luat, Aimee F; Juhász, Csaba et al. (2018) A Multidisciplinary Consensus for Clinical Care and Research Needs for Sturge-Weber Syndrome. Pediatr Neurol 84:11-20
Meybodi, Ali Tayebi; Kim, Helen; Nelson, Jeffrey et al. (2018) Surgical Treatment vs Nonsurgical Treatment for Brain Arteriovenous Malformations in Patients with Hereditary Hemorrhagic Telangiectasia: A Retrospective Multicenter Consortium Study. Neurosurgery 82:35-47
Offermann, Elizabeth A; Sreenivasan, Aditya; DeJong, M Robert et al. (2017) Reliability and Clinical Correlation of Transcranial Doppler Ultrasound in Sturge-Weber Syndrome. Pediatr Neurol 74:15-23.e5
Pilli, Vinod K; Chugani, Harry T; Juhász, Csaba (2017) Enlargement of deep medullary veins during the early clinical course of Sturge-Weber syndrome. Neurology 88:103-105
Kasthuri, Raj S; Montifar, Megan; Nelson, Jeffrey et al. (2017) Prevalence and predictors of anemia in hereditary hemorrhagic telangiectasia. Am J Hematol :
Zou, Xiaowei; Hart, Blaine L; Mabray, Marc et al. (2017) Automated algorithm for counting microbleeds in patients with familial cerebral cavernous malformations. Neuroradiology 59:685-690

Showing the most recent 10 out of 49 publications