Abstract

The Administrative Core is designed to ensure efficiency in the development, dissemination and application of new knowledge obtained by the Inherited Neuropathy Consortium (INC) RDCRC. The Central Administrative Core (CAC) is responsible for the overall administration of the INC and will oversee and coordinate interactions between the various components and projects of the INC. To achieve this goal, the CAC is comprised of Professor Michael Shy as the Director of INC RDCRC, Professor Steven Scherer as the Administrative Director, Professor David Herrmann as Clinical Liaison to the INC, Ms. Shawna Feely and Ms. Chelsea Bacon, as Clinical Coordinator and Assistant Clinical Coordinator. The Internal Advisory Board (IAB) will interact directly with the CAC on monthly conference calls. The IAB includes site PIs, the five INC Patient Advocacy Groups (PAGs), the INC Chief Biostatistician and DMCC representatives. We have added an International Liaison, a Diversity Liaison and Clinical Trial Committee to interact with the IAB. Finally, we will continue to interact with the INC External Advisory Committee (EAC) which is composed of internationally recognized investigators, PIs from additional RDCRC and representatives of the INC PAGs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54NS065712-13
Application #
10004174
Study Section
Special Emphasis Panel (ZTR1)
Project Start
2009-09-30
Project End
2024-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
13
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Johnson, Nicholas E; Heatwole, Chad; Creigh, Peter et al. (2018) The Charcot-Marie-Tooth Health Index: Evaluation of a Patient-Reported Outcome. Ann Neurol 84:225-233
Davies, Jenny L; Engelstad Sr.,, Janean K; E Gove, Linde et al. (2018) Somatotopic heat pain thresholds and intraepidermal nerve fibers in health. Muscle Nerve 58:509-516
Saghira, Cima; Bis, Dana M; Stanek, David et al. (2018) Variant pathogenicity evaluation in the community-driven Inherited Neuropathy Variant Browser. Hum Mutat 39:635-642
Shy, Michael; Rebelo, Adriana P; Feely, Shawna Me et al. (2018) Mutations in BAG3 cause adult-onset Charcot-Marie-Tooth disease. J Neurol Neurosurg Psychiatry 89:313-315
Laurá, Matilde; Singh, Dishan; Ramdharry, Gita et al. (2018) Prevalence and orthopedic management of foot and ankle deformities in Charcot-Marie-Tooth disease. Muscle Nerve 57:255-259
Hu, Bo; McCollum, Megan; Ravi, Vignesh et al. (2018) Myelin abnormality in Charcot-Marie-Tooth type 4J recapitulates features of acquired demyelination. Ann Neurol 83:756-770
Dankwa, Lois; Richardson, Jessica; Motley, William W et al. (2018) A mutation in the heptad repeat 2 domain of MFN2 in a large CMT2A family. J Peripher Nerv Syst 23:36-39
Bai, Yunhong; Wu, Xingyao; Brennan, Kathryn M et al. (2018) Myelin protein zero mutations and the unfolded protein response in Charcot Marie Tooth disease type 1B. Ann Clin Transl Neurol 5:445-455
Rebelo, Adriana P; Saade, Dimah; Pereira, Claudia V et al. (2018) SCO2 mutations cause early-onset axonal Charcot-Marie-Tooth disease associated with cellular copper deficiency. Brain 141:662-672
Abbott, Jamie A; Meyer-Schuman, Rebecca; Lupo, Vincenzo et al. (2018) Substrate interaction defects in histidyl-tRNA synthetase linked to dominant axonal peripheral neuropathy. Hum Mutat 39:415-432

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