Abstract

This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The focus will be to disseminate new discoveries, reagents, methods and technology to the greater biomedical community. In addition, there will be an effort to develop standards for data sharing and integration in collaboration with other TCNPs. The primary mode of datasharing will be traditional publication but we also plan to generate an especially useful web site tobroadcast some of the discoveries of the TCNP. An innovative mechanism for disseminating our discoveries will exploit Dr. Pandey''s relationship to the Institute of Bioinformatics in Bangalore, India. The development of data standards and ontologies will be extremely important for sharing and communicating data and information and is also developed by this core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54RR020839-04
Application #
7622850
Study Section
Special Emphasis Panel (ZRG1-BST-D (55))
Project Start
2007-08-01
Project End
2008-07-31
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
4
Fiscal Year
2007
Total Cost
$24,591
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Uzoma, Ijeoma; Hu, Jianfei; Cox, Eric et al. (2018) Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration. Mol Cell Proteomics 17:871-888
Cox, Eric; Hwang, Woochang; Uzoma, Ijeoma et al. (2017) Global Analysis of SUMO-Binding Proteins Identifies SUMOylation as a Key Regulator of the INO80 Chromatin Remodeling Complex. Mol Cell Proteomics 16:812-823
Newman, Heather A; Meluh, Pamela B; Lu, Jian et al. (2017) A high throughput mutagenic analysis of yeast sumo structure and function. PLoS Genet 13:e1006612
Noren, David P; Chou, Wesley H; Lee, Sung Hoon et al. (2016) Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses. Sci Signal 9:ra20
Sabari, Benjamin R; Tang, Zhanyun; Huang, He et al. (2015) Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation. Mol Cell 58:203-15
Wu, Zhixiang; Cheng, Zhongyi; Sun, Mingwei et al. (2015) A chemical proteomics approach for global analysis of lysine monomethylome profiling. Mol Cell Proteomics 14:329-39
Hu, Jianfei; Neiswinger, Johnathan; Zhang, Jin et al. (2015) Systematic Prediction of Scaffold Proteins Reveals New Design Principles in Scaffold-Mediated Signal Transduction. PLoS Comput Biol 11:e1004508
Liu, Shuang; Zhang, Hongyan; Dai, Jun et al. (2015) Characterization of monoclonal antibody's binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-9
Cubeñas-Potts, Caelin; Srikumar, Tharan; Lee, Christine et al. (2015) Identification of SUMO-2/3-modified proteins associated with mitotic chromosomes. Proteomics 15:763-72
Zhong, Jun; Martinez, Marissa; Sengupta, Srona et al. (2015) Quantitative phosphoproteomics reveals crosstalk between phosphorylation and O-GlcNAc in the DNA damage response pathway. Proteomics 15:591-607

Showing the most recent 10 out of 219 publications