This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Regarding AIDSBiomedical research institutions in Oregon are outstanding, and are prepared for a major expansion in clinical/translational investigation. We propose to form the Oregon Clinical and Translational Science Institute (OCTSI). The OCTSI will fundamentally change biomedical research to create a vibrant academic home forclinical/translational investigation. It will leverage existing strengths and remove barriers to the pace and growth of research. At the heart of the OCTSI is a robust partnership between Oregon Health & Science University (OHSU) and Kaiser Permanente's Center for Health Research (KPCHR) that brings together astrong biomedical research university and an innovative practice-based research center associated with a large patient population. The collaboration provides unique opportunities for expansion across the spectrum of human investigation, and sets the stage for major advances in human health. Transformation of clinical and translatlonal research in Oregon is enhanced by: ' Robust institutional support for the OCTSI, manifest by significant administrative change as well as the commitment of substantial financial and space resources ' Academic faculties at OHSU and KPCHR that fully support the OCTSI initiative and the development of astrong, multidisciplinary OCTSI leadership team ' Merging of resources to form a coordinated infrastructure for clinical/translational research ' Strong ties to the community and the involvement of the region in the human research agendaWe have identified three major goals for the OCTSI, and propose far-reaching, explicit and feasible approaches to achieve them. We will 1) Create an academic home (the OCTSI) specifically devoted to the discipline of clinical/translational research, 2) Nurture a new cadre of highly-trained, interdisciplinaryinvestigators through a strong, diverse educational curriculum, 3) Create a 'Research Commons' - a coordinated infrastructure of core research tools that greatly expands research opportunities and provides a unified, effective means for their access.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Linked Specialized Center Cooperative Agreement (UL1)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CR-3 (01))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Oregon Health and Science University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Farrell, Matthew J; Yahya, Jehan B; Degnin, Catherine et al. (2018) Prophylactic Cranial Irradiation for Limited-Stage Small-Cell Lung Cancer: Survey of US Radiation Oncologists on Current Practice Patterns. Clin Lung Cancer 19:371-376
Deyo, Richard A; Hallvik, Sara E; Hildebran, Christi et al. (2018) Use of prescription opioids before and after an operation for chronic pain (lumbar fusion surgery). Pain 159:1147-1154
Miller, Lyndsey M; Whitlatch, Carol J; Lee, Christopher S et al. (2018) Incongruent perceptions of the care values of hospitalized persons with dementia: a pilot study of patient-family caregiver dyads. Aging Ment Health 22:489-496
Deyo, Richard A; Hallvik, Sara E; Hildebran, Christi et al. (2018) Association of Prescription Drug Monitoring Program Use With Opioid Prescribing and Health Outcomes: A Comparison of Program Users and Nonusers. J Pain 19:166-177
Kohno, Milky; Loftis, Jennifer M; Huckans, Marilyn et al. (2018) The relationship between interleukin-6 and functional connectivity in methamphetamine users. Neurosci Lett 677:49-54
Orwoll, Eric S; Wiedrick, Jack; Jacobs, Jon et al. (2018) High-throughput serum proteomics for the identification of protein biomarkers of mortality in older men. Aging Cell 17:
Senders, Angela; Borgatti, Alena; Hanes, Douglas et al. (2018) Association Between Pain and Mindfulness in Multiple Sclerosis: A Cross-sectional Survey. Int J MS Care 20:28-34
Loy, Bryan D; Fling, Brett W; Horak, Fay B et al. (2018) Effects of lipoic acid on walking performance, gait, and balance in secondary progressive multiple sclerosis. Complement Ther Med 41:169-174
Miller, Lyndsey M; Lee, Christopher S; Whitlatch, Carol J et al. (2018) Involvement of Hospitalized Persons With Dementia in Everyday Decisions: A Dyadic Study. Gerontologist 58:644-653
Suri, Pradeep; Palmer, Melody R; Tsepilov, Yakov A et al. (2018) Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain. PLoS Genet 14:e1007601

Showing the most recent 10 out of 642 publications