Abstract

The immune response to the HIV involves an """"""""autoimmune"""""""" component in which the patient makes both anti-HIV antibody as well as anti-HLA antibody. This type of response can also be seen in other viral infections which can cause immune deficiencies. During an HIV infection it appears that the older patients suffer a more extensive loss of T helper cells and reach lower levels more rapidly than do younger patients. Younger HIV infected patients can actually go through extended periods in which their CD4+ cell level remains in the normal range.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000441-06
Application #
3767820
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Giri, Banabihari; Dixit, Vishwa D; Ghosh, Manik C et al. (2007) CXCL12-induced partitioning of flotillin-1 with lipid rafts plays a role in CXCR4 function. Eur J Immunol 37:2104-16
Nguyen, Dzung H; Giri, Banabihari; Collins, Gary et al. (2005) Dynamic reorganization of chemokine receptors, cholesterol, lipid rafts, and adhesion molecules to sites of CD4 engagement. Exp Cell Res 304:559-69
Galey, D; Becker, K; Haughey, N et al. (2003) Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes. J Neurovirol 9:358-71
Kalayjian, Robert C; Landay, Alan; Pollard, Richard B et al. (2003) Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes. J Infect Dis 187:1924-33
Zingmond, David S; Kilbourne, Amy M; Justice, Amy C et al. (2003) Differences in symptom expression in older HIV-positive patients: The Veterans Aging Cohort 3 Site Study and HIV Cost and Service Utilization Study experience. J Acquir Immune Defic Syndr 33 Suppl 2:S84-92
Nguyen, Dzung H; Taub, Dennis (2002) CXCR4 function requires membrane cholesterol: implications for HIV infection. J Immunol 168:4121-6
Mascarucci, Paolo; Taub, Dennis; Saccani, Simona et al. (2002) Cytokine responses in young and old rhesus monkeys: effect of caloric restriction. J Interferon Cytokine Res 22:565-71
Nguyen, Dzung H; Taub, Dennis (2002) Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5. Blood 99:4298-306
Mascarucci, P; Taub, D; Saccani, S et al. (2001) Age-related changes in cytokine production by leukocytes in rhesus monkeys. Aging (Milano) 13:85-94
Tedla, N; Dwyer, J; Truskett, P et al. (1999) Phenotypic and functional characterization of lymphocytes derived from normal and HIV-1-infected human lymph nodes. Clin Exp Immunol 117:92-9