The technique of X-ray crystallography, essential to our attempts at structure-assisted vaccine design, is dependent on the relatively poorly uunderstood process of protein crystallization. A central stumbling block in our investigations of the HIV-1 envelope has been the difficulty in obtaining well-diffracting crystals. To solve this problem, we have focused on developing methods to enhance the probability of crystallization.
Huang, Chih-chin; Tang, Min; Zhang, Mei-Yun et al. (2005) Structure of a V3-containing HIV-1 gp120 core. Science 310:1025-8 |
Majeed, Shahzad; Ofek, Gilad; Belachew, Adam et al. (2003) Enhancing protein crystallization through precipitant synergy. Structure 11:1061-70 |