We analyzed tumor cell lines for FGF receptor expression. Our results indicate that the FLG-FLG receptor and basic FGF may be involved in autocrine stimulation in rhabdomyosarcomas. Similarly, our results indicate that the FLG-FGF receptor and acidic FGF may be involved in autocrine stimulation in glial tumors. The expression pattern or this receptor differs significantly from a second FGF receptor BEK. The difference in the roles of these two receptors remains unclear. Recent evidence indicates that the FLG-FGF receptor is also the HSV 1 receptor. The pattern of expression is a value both for the FGF receptor studies and as a means of determining potentialsites of HSV infection.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC006024-02
Application #
3811163
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code