VP-1-16 undergoes demethylation to generate active intermediates that binds to protein and DNA. The demethylation is P450 dependent. The generation of the reactive intermediates from VP-16 may be related to its biological activities.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CM006523-01
Application #
4692136
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Cancer Treatment
Department
Type
DUNS #
City
State
Country
United States
Zip Code