The mechanisms responsible for the alteration of chemical carcinogenesis by the dietary lipotropes, choline, methioine, folic acid and vitamin B-12, have been studied. The metabolism and carcinogenic activity of ethionine in different species is being compared. Correlations between the tissue levels of the physiological methyl donor S-adenosylmethionine, its chief metabolic inhibitor, S-adeno-sylhomocysteine, and 5-methylcytosine in animals treated with carcinogens, liver tumor promoters and methyl-deficient diets are being determined. Using standard bioassays the effects of (1) the length of time of dietary methyl deprivation, (2) the interaction between methyl deprivation and liver tumor promoters, and (3) deficiencies of other essential nutrients on hepatocarcinogenesis are under investigation. The effects of carcinogens and methylase inhibitors on the general and specific methylation of DNA in target tissues are examined.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP004580-12
Application #
4692290
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code