Work on the interdependence of neurons and glia has focused not only on CO2 fixation in astroglial cells but also in 13C-glucose metabolism in these cells. Astroglia, in culture, have been found to release products of C02 fixation into the surrounding medium with only a relatively small fraction of the products remaining in the cells. In mixed cultures of astroglial and neurons, however, approximately 90% of the labelled products were found within the cells suggesting that when these cells are in intimate contact there is a transfer of products from one cell to anther rather than a release of products into the extracellular medium. The anapleoric C02 fixation reaction occurring in glial cells may therefore serve to replenish essential metabolites in both neurons and astroglial cells.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002414-05
Application #
3845261
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code