We have developed a variety of tasks to activate regions of interest in functional neuroimaging studies. 1. We are developing a Continuous Performance Test of attention and encoding to be used in event related fMRI. While behavioral deficits have been widely reported in schizophrenic patients, the neural substrate of this task has yet to be elucidated. 2. We developed a carefully matched set of verbal fluency tasks to examine the relation between semantic processing, thought disorder, and neurophysiology in schizophrenia using PET CBF methods. We arel also using a semantic processing task in fMRI to determine the physiologic concomitants of aberrations in semantic space. 3. To examine the levels of processing account of episodic memory we devised a series or recognition memory tasks. We also paid special attention to the development of a control task that would not involve active processing so as to better observe hippocampal activation. - cognition schizophrenia neuroimaging - Human Subjects: Interview, Questionaires, or Surveys Only

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002711-05
Application #
6290575
Study Section
Special Emphasis Panel (CBDB)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Diaz-Asper, Catherine M; Weinberger, Daniel R; Goldberg, Terry E (2006) Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics. NeuroRx 3:97-105
Mattay, Venkata S; Fera, Francesco; Tessitore, Alessandro et al. (2006) Neurophysiological correlates of age-related changes in working memory capacity. Neurosci Lett 392:32-7
Talamini, Lucia M; Meeter, Martijn; Elvevag, Brita et al. (2005) Reduced parahippocampal connectivity produces schizophrenia-like memory deficits in simulated neural circuits with reduced parahippocampal connectivity. Arch Gen Psychiatry 62:485-93
Paul, Brianna M; Elvevag, Brita; Bokat, Christina E et al. (2005) Levels of processing effects on recognition memory in patients with schizophrenia. Schizophr Res 74:101-10
Simmons, Alan; Miller, Daniel; Feinstein, Justin S et al. (2005) Left inferior prefrontal cortex activation during a semantic decision-making task predicts the degree of semantic organization. Neuroimage 28:30-8
Cohen, Jessica R; Elvevag, Brita; Goldberg, Terry E (2005) Cognitive control and semantics in schizophrenia: an integrated approach. Am J Psychiatry 162:1969-71
Callicott, Joseph H; Straub, Richard E; Pezawas, Lukas et al. (2005) Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Natl Acad Sci U S A 102:8627-32
Fera, Francesco; Weickert, Thomas W; Goldberg, Terry E et al. (2005) Neural mechanisms underlying probabilistic category learning in normal aging. J Neurosci 25:11340-8
Foltynie, Thomas; Lewis, Simon G J; Goldberg, Terry E et al. (2005) The BDNF Val66Met polymorphism has a gender specific influence on planning ability in Parkinson's disease. J Neurol 252:833-8
Weickert, Thomas W; Goldberg, Terry E (2005) First- and second-generation antipsychotic medication and cognitive processing in schizophrenia. Curr Psychiatry Rep 7:304-10

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