Clinical And Therapeutic Studies Of Human Filariasis and Related Diseases

Nutman, Thomas

Abstract

To understand better the pathogenesis of filarial infections (onchocerciasis, loiaisis, lymphatic filarasis) clinical assessments of patients with these and other related non-filarial (strongyloides, malaria) infections have been studied in detail. The influence that filarial infections have on the clinical expression of non-filarial infectious diseases have also been studied by performing clinical trials in filarial-endemic regions of the world that are co-endemic for malaria (Mali), tuberculosis (India) and HIV (India). New diagnostic approaches have been developed and utilized for the rapid and specific diagnosis of Strongyloidiasis, loiasis, and onchocerciasis. Rapid (almost point of care) diagnostics have been developed for surveillance of W. bancrofti and O. volvulus following mass drug distribution campaigns. A potential vaccine candidate for S. stercoralis has been identified.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIAAI000439-29
• Application #: 8745298
• Support Year: 29
• Fiscal Year: 2013
• Total Cost: $811,167

Institution

• Name: National Institute of Allergy and Infectious Diseases

Publications

Won, Kimberly Y; Robinson, Keri; Hamlin, Katy L et al. (2018) Comparison of antigen and antibody responses in repeat lymphatic filariasis transmission assessment surveys in American Samoa. PLoS Negl Trop Dis 12:e0006347

Emukah, Emmanuel; Rakers, Lindsay J; Kahansim, Barminas et al. (2018) In Southern Nigeria Loa loa Blood Microfilaria Density is Very Low Even in Areas with High Prevalence of Loiasis: Results of a Survey Using the New LoaScope Technology. Am J Trop Med Hyg 99:116-123

Sangare, Moussa Brema; Coulibaly, Yaya Ibrahim; Coulibaly, Siaka Yamoussa et al. (2018) A cross-sectional study of the filarial and Leishmania co-endemicity in two ecologically distinct settings in Mali. Parasit Vectors 11:18

Kwan, Jennifer L; Seitz, Amy E; Fried, Michal et al. (2018) Seroepidemiology of helminths and the association with severe malaria among infants and young children in Tanzania. PLoS Negl Trop Dis 12:e0006345

O'Connell, Elise M; Mitchell, Tarissa; Papaiakovou, Marina et al. (2018) Ancylostoma ceylanicum Hookworm in Myanmar Refugees, Thailand, 2012-2015. Emerg Infect Dis 24:

Colebunders, Robert; Mandro, Michel; Njamnshi, Alfred K et al. (2018) Report of the first international workshop on onchocerciasis-associated epilepsy. Infect Dis Poverty 7:23

Dolo, Housseini; Coulibaly, Yaya Ibrahim; Kelly-Hope, Louise et al. (2018) Factors Associated with Wuchereria bancrofti Microfilaremia in an Endemic Area of Mali. Am J Trop Med Hyg 98:1782-1787

Kamgno, Joseph; Nana-Djeunga, Hugues C; Pion, Sébastien D et al. (2018) Operationalization of the test and not treat strategy to accelerate the elimination of onchocerciasis and lymphatic filariasis in Central Africa. Int Health 10:i49-i53

Mitchell, Tarissa; Lee, Deborah; Weinberg, Michelle et al. (2018) Impact of Enhanced Health Interventions for United States-Bound Refugees: Evaluating Best Practices in Migration Health. Am J Trop Med Hyg 98:920-928

Drame, Papa M; Bennuru, Sasisekhar; Nutman, Thomas B (2017) Discovery of Specific Antigens That Can Predict Microfilarial Intensity in Loa loa Infection. J Clin Microbiol 55:2671-2678