Abstract

1) NTM prevalence in closed health care systems: During FY2008-2009 we finalized analytic datasets from four Health Maintenance Organizations representing a combined population of nearly 4 million persons and four geographic areas of the United States (Southern California, Pacific Northwest, Southwest, Mid-Atlantic). These sites combined represent a total of 49 years of observation, ranging from 10 years-16 years. Analysis of these data is in progress and we expect to complete the analysis and manuscript within the next 3 months. 2) Hospital discharge data : During FY2008-09 we completed analysis of hospital discharges associated with nontuberculous mycobacteria from 11 states representing nearly half of all hospital discharges during 1988-2005. During that period, a total of 116,548 hospital discharges were identified associated with the ICD9 code for pulmonary NTM, of which 40,533 were not associated with AIDS. The manuscript based on this analysis will be published in 2009. In addition, we completed an analysis of bronchiectasis-associated hospitalizations and are finalizing the manuscript.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI001035-02
Application #
7964662
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2009
Total Cost
$223,692
Indirect Cost

  Institution

Name
National Institute of Allergy and Infectious Diseases
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Adjemian, Jennifer; Daniel-Wayman, Shelby; Ricotta, Emily et al. (2018) Epidemiology of Nontuberculous Mycobacteriosis. Semin Respir Crit Care Med 39:325-335
Adjemian, Jennifer; Olivier, Kenneth N; Prevots, D Rebecca (2018) Epidemiology of Pulmonary Nontuberculous Mycobacterial Sputum Positivity in Patients with Cystic Fibrosis in the United States, 2010-2014. Ann Am Thorac Soc 15:817-826
van Ingen, Jakko; Wagner, Dirk; Gallagher, Jack et al. (2017) Poor adherence to management guidelines in nontuberculous mycobacterial pulmonary diseases. Eur Respir J 49:
Adjemian, Jennifer; Frankland, Timothy B; Daida, Yihe G et al. (2017) Epidemiology of Nontuberculous Mycobacterial Lung Disease and Tuberculosis, Hawaii, USA. Emerg Infect Dis 23:439-447
Spaulding, Alicen B; Lai, Yi Ling; Zelazny, Adrian M et al. (2017) Geographic Distribution of Nontuberculous Mycobacterial Species Identified among Clinical Isolates in the United States, 2009-2013. Ann Am Thorac Soc :
Prevots, D Rebecca; Loddenkemper, Robert; Sotgiu, Giovanni et al. (2017) Nontuberculous mycobacterial pulmonary disease: an increasing burden with substantial costs. Eur Respir J 49:
Henkle, Emily; Novosad, Shannon A; Shafer, Sean et al. (2017) Long-Term Outcomes in a Population-based Cohort with Respiratory Nontuberculous Mycobacteria Isolation. Ann Am Thorac Soc 14:1120-1128
Henkle, Emily; Aksamit, Timothy; Barker, Alan et al. (2016) Patient-Centered Research Priorities for Pulmonary Nontuberculous Mycobacteria (NTM) Infection. An NTM Research Consortium Workshop Report. Ann Am Thorac Soc 13:S379-84
Fleshner, M; Olivier, K N; Shaw, P A et al. (2016) Mortality among patients with pulmonary non-tuberculous mycobacteria disease. Int J Tuberc Lung Dis 20:582-7
Winthrop, Kevin L; Ku, Jennifer H; Marras, Theodore K et al. (2015) The tolerability of linezolid in the treatment of nontuberculous mycobacterial disease. Eur Respir J 45:1177-9

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