In 2010, we published the first description of a genetically unique strain of Lassa virus isolated from Mastomys natalensis captured in Mali, an area previously thought to be Lassa virus free (Safronetz et al. 2010). Over the last four years we have continued to conduct field studies mapping the geographic distribution of Lassa virus in peridomestic settings across sub-Saharan Mali. With a better understanding of the regions endemic for this virus in Mali, the Lassa program is transitioning into studies aimed at defining the infection dynamics and transmissibility of Lassa in the natural rodent hosts, as well as defining the incidence rates of Lassa virus infection in humans. The Mali field program has now expanded to include other zoonotic viruses including surveillance for additional arenaviruses, hantaviruses, MERS-CoV, and CCHFV, as well as rodent-specific pathogens including cytomegalovirus.
| Subudhi, Sonu; Dakouo, Martin; Sloan, Angela et al. (2018) Seroprevalence of Rift Valley Fever Virus Antibodies in Cattle in Mali, 2005-2014. Am J Trop Med Hyg 98:872-874 |
| Hawman, David W; Haddock, Elaine; Meade-White, Kimberly et al. (2018) Favipiravir (T-705) but not ribavirin is effective against two distinct strains of Crimean-Congo hemorrhagic fever virus in mice. Antiviral Res 157:18-26 |
| Zivcec, Marko; Safronetz, David; Scott, Dana P et al. (2018) Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge. PLoS Negl Trop Dis 12:e0006628 |
| Rosenke, Kyle; Feldmann, Heinz; Westover, Jonna B et al. (2018) Use of Favipiravir to Treat Lassa Virus Infection in Macaques. Emerg Infect Dis 24:1696-1699 |
| Rosenke, Kyle; Mercado-Hernandez, Reinaldo; Cronin, Jacqueline et al. (2018) The Effect of Plasmodium on the Outcome of Ebola Virus Infection in a Mouse Model. J Infect Dis : |
| Haddock, Elaine; Feldmann, Friederike; Hawman, David W et al. (2018) A cynomolgus macaque model for Crimean-Congo haemorrhagic fever. Nat Microbiol 3:556-562 |
| Strong, James E; Feldmann, Heinz (2017) The Crux of Ebola Diagnostics. J Infect Dis 216:1340-1342 |
| Prescott, Joseph B; Marzi, Andrea; Safronetz, David et al. (2017) Immunobiology of Ebola and Lassa virus infections. Nat Rev Immunol 17:195-207 |
| Safronetz, David; Sogoba, Nafomon; Diawara, Sory Ibrahim et al. (2017) Annual Incidence of Lassa Virus Infection in Southern Mali. Am J Trop Med Hyg 96:944-946 |
| Falzarano, Darryl; Kamissoko, Badian; de Wit, Emmie et al. (2017) Dromedary camels in northern Mali have high seropositivity to MERS-CoV. One Health 3:41-43 |
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