The dose-adjusted EPOCH regimen was developed based on in vitro and pharmacodynamic principals to help overcome drug resistance12. In this regimen, doxorubicin, vincristine, and etoposide are administered as a 96-hour continuous infusion, and cyclophosphamide and prednisone are administered on a bolus schedule. The rationale for the administration schedule derived from the laboratory observation that human tumor cell lines, including those with a multi-drug resistance phenotype, are more sensitive to cytotoxic natural products given for prolonged periods at low concentrations than to the same agents given for brief periods at higher concentrations. Multiple phase II studies suggests it is superior to R-CHOP, possibly due to overcoming tumor proliferation and increasing cell tumor cell kill. If superior to R-CHOP, it will increase the cure of DLBCL.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC010728-05
Application #
8157416
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2010
Total Cost
$116,526
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Degheidy, Heba A; Venzon, David J; Farooqui, Mohammed Z H et al. (2012) Combined normal donor and CLL: Single tube ZAP-70 analysis. Cytometry B Clin Cytom 82:67-77
Wilson, Wyndham H; Jung, Sin-Ho; Porcu, Pierluigi et al. (2012) A Cancer and Leukemia Group B multi-center study of DA-EPOCH-rituximab in untreated diffuse large B-cell lymphoma with analysis of outcome by molecular subtype. Haematologica 97:758-65
Royo, C; Navarro, A; Clot, G et al. (2012) Non-nodal type of mantle cell lymphoma is a specific biological and clinical subgroup of the disease. Leukemia 26:1895-8
Dunleavy, Kieron; Roschewski, Mark; Wilson, Wyndham H (2012) Lymphomatoid granulomatosis and other Epstein-Barr virus associated lymphoproliferative processes. Curr Hematol Malig Rep 7:208-15
Roschewski, Mark; Wilson, Wyndham H (2012) EBV-associated lymphomas in adults. Best Pract Res Clin Haematol 25:75-89
Eberle, Franziska C; Song, Joo Y; Xi, Liqiang et al. (2012) Nodal involvement by cutaneous CD30-positive T-cell lymphoma mimicking classical Hodgkin lymphoma. Am J Surg Pathol 36:716-25
Dunleavy, Kieron; Grant, Cliona; Eberle, Franziska C et al. (2012) Gray zone lymphoma: better treated like hodgkin lymphoma or mediastinal large B-cell lymphoma? Curr Hematol Malig Rep 7:241-7
Dunleavy, Kieron; Wilson, Wyndham H (2012) How I treat HIV-associated lymphoma. Blood 119:3245-55
Herishanu, Yair; Perez-Galan, Patricia; Liu, Delong et al. (2011) The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood 117:563-74
Mansoor, Adnan; Pittaluga, Stefania; Beck, Paul L et al. (2011) NK-cell enteropathy: a benign NK-cell lymphoproliferative disease mimicking intestinal lymphoma: clinicopathologic features and follow-up in a unique case series. Blood 117:1447-52

Showing the most recent 10 out of 23 publications