In fiscal year 2009, we completed the initial comprehensive sampling of multiple skin sites in ten healthy volunteers with repeat sampling in 5 of 10 volunters. The multi-site survey was published in Science magazine. We are currently using that data to inform the atopic dermatitis part of the project as well as to provide overall knowledge of diversity of skin microbes that can be utilized in the National Institutes of Health Roadmap Project, The Human Microbiome Project. We have initiated recruitment of atopic dermatitis (eczema) patients and healthy controls for sampling. In addition to continuing recruitment, we have begun to sequence already obtained skin samples.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC010938-02
Application #
7965849
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2009
Total Cost
$52,615
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Kennedy, Elizabeth A; Connolly, Jennifer; Hourihane, Jonathan O'B et al. (2017) Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year. J Allergy Clin Immunol 139:166-172
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Oh, Julia; Byrd, Allyson L; Park, Morgan et al. (2016) Temporal Stability of the Human Skin Microbiome. Cell 165:854-66
Jo, Jay-Hyun; Kennedy, Elizabeth A; Kong, Heidi H (2016) Research Techniques Made Simple: Bacterial 16S Ribosomal RNA Gene Sequencing in Cutaneous Research. J Invest Dermatol 136:e23-e27

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