We have made steady progress in the past year. We have produced and bred mouse colonies in which TGFbeta R2 receptor is specifically deleted in host immature myeloid cells. We have observed significantly decreased tumor progression in myeloid TGFbeta R2 ko mice. We are currently investigating mechanisms which involves systemic immune response as well as direct interaction of myeloid cells with tumor cells in the microenvironment and distant metastatic organ. We hope to develop new translational opportunities with the research information obtained. We are utilizing technical core resources and collaborating with several labs for this project.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
National Cancer Institute Division of Basic Sciences
Zip Code
Yan, Hangyi H; Jiang, Jian; Pang, Yanli et al. (2015) CCL9 Induced by TGF? Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ. Cancer Res 75:5283-98
Luger, Dror; Yang, Yu-An; Raviv, Asaf et al. (2013) Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects. PLoS One 8:e76115
Pang, Yanli; Gara, Sudheer Kumar; Achyut, Bhagelu R et al. (2013) TGF-? signaling in myeloid cells is required for tumor metastasis. Cancer Discov 3:936-51
Yang, Li (2010) TGFbeta and cancer metastasis: an inflammation link. Cancer Metastasis Rev 29:263-71
Yang, Li; Pang, Yanli; Moses, Harold L (2010) TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression. Trends Immunol 31:220-7
Yang, Li; Edwards, Claire M; Mundy, Gregory R (2010) Gr-1+CD11b+ myeloid-derived suppressor cells: formidable partners in tumor metastasis. J Bone Miner Res 25:1701-6
Yang, L (2010) TGFbeta, a potent regulator of tumor microenvironment and host immune response, implication for therapy. Curr Mol Med 10:374-80
Hembruff, Stacey L; Jokar, Iman; Yang, Li et al. (2010) Loss of transforming growth factor-beta signaling in mammary fibroblasts enhances CCL2 secretion to promote mammary tumor progression through macrophage-dependent and -independent mechanisms. Neoplasia 12:425-33