Infection, immune disturbances, and inflammation overlap in the ways that they damage tissues and promote development of cancer. Major studies under this project include the HIV/AIDS Cancer Match Study and Transplant Cancer Match Study, which link population-based registries of HIV infected people and transplant recipients to cancer registries in the U.S. Additional studies characterize risk factors for specific cancers in these immunosuppressed populations. Risk of non-Hodgkin lymphoma and lung cancer is elevated in immunosuppressed populations. Other cancers of interest, because they are associated with HIV or organ transplant, include Kaposi sarcoma, liver cancer, cancers related to human papillomavirus (such as cervical cancer and anal cancer), Hodgkin lymphoma, melanoma, non-melanoma skin cancers, kidney cancer, and multiple myeloma. Some studies under this project address the role of chronic infections, immune disturbance, and inflammation in these and other cancers. One study under this project is a case-control study of GB virus C and non-Hodgkin lymphoma. Other studies, which focus on cancer risk in the elderly, involve analyses of linked SEER Medicare registry data.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Investigator-Initiated Intramural Research Projects (ZIA)
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Division of Cancer Epidemiology and Genetics
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Mahale, Parag; Engels, Eric A; Coghill, Anna E et al. (2018) Cancer Risk in Older Persons Living With Human Immunodeficiency Virus Infection in the United States. Clin Infect Dis 67:50-57
Shiels, Meredith S; Freedman, Neal D; Thomas, David et al. (2018) Trends in U.S. Drug Overdose Deaths in Non-Hispanic Black, Hispanic, and Non-Hispanic White Persons, 2000-2015. Ann Intern Med 168:453-455
Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521
Mahale, Parag; Shiels, Meredith S; Lynch, Charles F et al. (2018) Incidence and outcomes of primary central nervous system lymphoma in solid organ transplant recipients. Am J Transplant 18:453-461
Gupta, Gaurav; Kuppachi, Sarat; Kalil, Roberto S et al. (2018) Treatment for presumed BK polyomavirus nephropathy and risk of urinary tract cancers among kidney transplant recipients in the United States. Am J Transplant 18:245-252
Shiels, Meredith S; Islam, Jessica Y; Rosenberg, Philip S et al. (2018) Projected Cancer Incidence Rates and Burden of Incident Cancer Cases in HIV-Infected Adults in the United States Through 2030. Ann Intern Med 168:866-873
Shiels, Meredith S; Kirk, Gregory D; Drummond, M Bradley et al. (2018) HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D. J Infect Dis 217:413-417
Colón-López, Vivian; Shiels, Meredith S; Machin, Mark et al. (2018) Anal Cancer Risk Among People With HIV Infection in the United States. J Clin Oncol 36:68-75
Hernández-Ramírez, Raúl U; Shiels, Meredith S; Dubrow, Robert et al. (2017) Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage study. Lancet HIV 4:e495-e504
Howlader, Nadia; Mariotto, Angela B; Besson, Caroline et al. (2017) Cancer-specific mortality, cure fraction, and noncancer causes of death among diffuse large B-cell lymphoma patients in the immunochemotherapy era. Cancer 123:3326-3334

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