We continue to develop mathematical models of human metabolism and have conducted several validation studies using a variety of published data on the metabolic responses to overfeeding, underfeeding, and isocaloric changes in dietary macronutrients. Our models have been deployed as a clinical research tool in collaboration with NIH clinical investigators to help design prospective studies as well as plan and track clinical weight management programs. Our models are being applied to a variety of problems, from calculating the relationship between human weight change and food intake to calculating changes of free-living energy intake using frequent body weight measurements.

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Guo, Juen; Brager, Danielle C; Hall, Kevin D (2018) Simulating long-term human weight-loss dynamics in response to calorie restriction. Am J Clin Nutr 107:558-565
Hall, Kevin D; Kahan, Scott (2018) Maintenance of Lost Weight and Long-Term Management of Obesity. Med Clin North Am 102:183-197
Hall, Kevin D; Schoeller, Dale A; Brown, Andrew W (2018) Reducing Calories to Lose Weight. JAMA 319:2336-2337
Hall, Kevin D; Sanghvi, Arjun; Göbel, Britta (2017) Proportional Feedback Control of Energy Intake During Obesity Pharmacotherapy. Obesity (Silver Spring) 25:2088-2091
Hall, Kevin D; Guo, Juen (2017) Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition. Gastroenterology 152:1718-1727.e3
Katan, Martijn B; de Ruyter, Janne C; Kuijper, Lothar D J et al. (2016) Impact of Masked Replacement of Sugar-Sweetened with Sugar-Free Beverages on Body Weight Increases with Initial BMI: Secondary Analysis of Data from an 18 Month Double-Blind Trial in Children. PLoS One 11:e0159771
MacLeod, Erin L; Hall, Kevin D; McGuire, Peter J (2016) Computational modeling to predict nitrogen balance during acute metabolic decompensation in patients with urea cycle disorders. J Inherit Metab Dis 39:17-24
Polidori, David; Sanghvi, Arjun; Seeley, Randy J et al. (2016) How Strongly Does Appetite Counter Weight Loss? Quantification of the Feedback Control of Human Energy Intake. Obesity (Silver Spring) 24:2289-2295
Freedhoff, Yoni; Hall, Kevin D (2016) Weight loss diet studies: we need help not hype. Lancet 388:849-51
Vandevijvere, Stefanie; Chow, Carson C; Hall, Kevin D et al. (2015) Increased food energy supply as a major driver of the obesity epidemic: a global analysis. Bull World Health Organ 93:446-56

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