Abstract

We continue to develop mathematical models of human metabolism and have recently modeled childhood growth and the development and treatment of childhood obesity. We have also tested the utility of our models in application clinical weight loss data from a medically supervised weight loss program and we found that model simulations could provide important clinical information about adherence to the program. We have continued to develop our methods for using repeated data on body weight changes to quantify the time course of calorie intake during a variety of interventions, including obesity pharmacotherapy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADK013036-08
Application #
8939490
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Guo, Juen; Brager, Danielle C; Hall, Kevin D (2018) Simulating long-term human weight-loss dynamics in response to calorie restriction. Am J Clin Nutr 107:558-565
Hall, Kevin D; Kahan, Scott (2018) Maintenance of Lost Weight and Long-Term Management of Obesity. Med Clin North Am 102:183-197
Hall, Kevin D; Schoeller, Dale A; Brown, Andrew W (2018) Reducing Calories to Lose Weight. JAMA 319:2336-2337
Hall, Kevin D; Sanghvi, Arjun; Göbel, Britta (2017) Proportional Feedback Control of Energy Intake During Obesity Pharmacotherapy. Obesity (Silver Spring) 25:2088-2091
Hall, Kevin D; Guo, Juen (2017) Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition. Gastroenterology 152:1718-1727.e3
Katan, Martijn B; de Ruyter, Janne C; Kuijper, Lothar D J et al. (2016) Impact of Masked Replacement of Sugar-Sweetened with Sugar-Free Beverages on Body Weight Increases with Initial BMI: Secondary Analysis of Data from an 18 Month Double-Blind Trial in Children. PLoS One 11:e0159771
MacLeod, Erin L; Hall, Kevin D; McGuire, Peter J (2016) Computational modeling to predict nitrogen balance during acute metabolic decompensation in patients with urea cycle disorders. J Inherit Metab Dis 39:17-24
Polidori, David; Sanghvi, Arjun; Seeley, Randy J et al. (2016) How Strongly Does Appetite Counter Weight Loss? Quantification of the Feedback Control of Human Energy Intake. Obesity (Silver Spring) 24:2289-2295
Freedhoff, Yoni; Hall, Kevin D (2016) Weight loss diet studies: we need help not hype. Lancet 388:849-51
Vandevijvere, Stefanie; Chow, Carson C; Hall, Kevin D et al. (2015) Increased food energy supply as a major driver of the obesity epidemic: a global analysis. Bull World Health Organ 93:446-56

Showing the most recent 10 out of 45 publications