Gastrinomas are the most common symptomatic, malignant pancreatic neuroendocrine tumor (pNET) in patients with or without MEN1 and sufficient numbers of these patients have been entered into our protocols to allow systematic assessment. A number of different studies were completed this year including one focused on parathyroid surgery in MEN1 patients; and an analysis of the changing natural history of MEN1 patients. During this year information from our prospective studies was used to write four guideline and position papers dealing with the diagnosis of these tumors, treatment of advanced disease and pharmacological approach to management. Furthermore, one chapter was co-authored with Prof J.A. Norton (Stanford) on surgical treatment of gastrinomas.

Project Start
Project End
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Budget End
Support Year
25
Fiscal Year
2016
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Indirect Cost
Name
U.S. National Inst Diabetes/Digst/Kidney
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Norton, Jeffrey A; Krampitz, Geoffrey W; Poultsides, George A et al. (2018) Prospective Evaluation of Results of Reoperation in Zollinger-Ellison Syndrome. Ann Surg 267:782-788
Ito, Tetsuhide; Lee, Lingaku; Jensen, Robert T (2018) Carcinoid-syndrome: recent advances, current status and controversies. Curr Opin Endocrinol Diabetes Obes 25:22-35
Capdevila, Jaume; Bodei, Lisa; Davies, Philippa et al. (2018) UNMET MEDICAL NEEDS IN METASTATIC LUNG AND DIGESTIVE NEUROENDOCRINE NEOPLASMS. Neuroendocrinology :
Lee, Lingaku; Ito, Tetsuhide; Jensen, Robert T (2018) Imaging of pancreatic neuroendocrine tumors: recent advances, current status, and controversies. Expert Rev Anticancer Ther 18:837-860
Lee, Lingaku; Ito, Tetsuhide; Jensen, Robert T (2018) Everolimus in the treatment of neuroendocrine tumors: efficacy, side-effects, resistance, and factors affecting its place in the treatment sequence. Expert Opin Pharmacother 19:909-928
Norton, Jeffrey A.; Foster, Deshka S.; Blumgart, Leslie H. et al. (2018) Incidence and Prognosis of Primary Gastrinomas in the Hepatobiliary Tract. JAMA Surg 153:e175083
Lee, Lingaku; Ito, Tetsuhide; Igarashi, Hisato et al. (2018) Dose and schedule modification are required for long-term continuation of sunitinib in Japanese patients with advanced pancreatic neuroendocrine tumors. Cancer Chemother Pharmacol 81:163-169
Foster, Deshka S; Jensen, Robert; Norton, Jeffrey A (2018) Management of Liver Neuroendocrine Tumors in 2018. JAMA Oncol :
Ueda, Keijiro; Kawabe, Ken; Lee, Lingaku et al. (2017) Diagnostic Performance of 48-Hour Fasting Test and Insulin Surrogates in Patients With Suspected Insulinoma. Pancreas 46:476-481
Jensen, Robert T; Norton, Jeffrey A (2017) Treatment of Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1: Some Clarity But Continued Controversy. Pancreas 46:589-594

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