The sphingolipid metabolic pathway yields highly active lipid signaling molecules that regulate many physiologic processes during development and for homeostasis in the adult. Furthermore, the pathway is highly regulated and appears to function abnormally in certain disordered states such as in cancer and in metabolic diseases. We are utilizing genetically altered mice that are modified in their sphingolipid metabolism and signaling to uncover new functions of sphingolipids in normal biology and in disease.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Zip Code
Xu, Lingyan; Ma, Xinran; Verma, Narendra Kumar et al. (2018) Ablation of PPAR? in subcutaneous fat exacerbates age-associated obesity and metabolic decline. Aging Cell 17:
Kulinski, Joseph M; Proia, Richard L; Larson, Elisabeth M et al. (2018) S1P? Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells. Int J Mol Sci 19:
Feuerborn, Renata; Besser, Manuela; Potì, Francesco et al. (2018) Elevating Endogenous Sphingosine-1-Phosphate (S1P) Levels Improves Endothelial Function and Ameliorates Atherosclerosis in Low Density Lipoprotein Receptor-Deficient (LDL-R-/-) Mice. Thromb Haemost 118:1470-1480
Alexaki, Aikaterini; Clarke, Benjamin A; Gavrilova, Oksana et al. (2017) De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis. J Biol Chem 292:3929-3939
Kono, Mari; Conlon, Elizabeth G; Lux, Samantha Y et al. (2017) Bioluminescence imaging of G protein-coupled receptor activation in living mice. Nat Commun 8:1163
Xiong, Yuquan; Lee, Hyuek Jong; Mariko, Boubacar et al. (2016) Sphingosine kinases are not required for inflammatory responses in macrophages. J Biol Chem 291:11465
Weth-Malsch, Daniela; Langeslag, Michiel; Beroukas, Dimitra et al. (2016) Ablation of Sphingosine 1-Phosphate Receptor Subtype 3 Impairs Hippocampal Neuron Excitability In vitro and Spatial Working Memory In vivo. Front Cell Neurosci 10:258
Taguchi, Yoshimitsu; Allende, Maria L; Mizukami, Hiroki et al. (2016) Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet ?-Cell Endoplasmic Reticulum Stress and Proliferation. J Biol Chem 291:12029-38
Proia, Richard L; Hla, Timothy (2015) Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J Clin Invest 125:1379-87
Kono, Mari; Proia, Richard L (2015) Imaging S1P1 activation in vivo. Exp Cell Res 333:178-82

Showing the most recent 10 out of 43 publications