The overarching goals of the NICHD Fetal Growth Studies are to 1) determine optimal growth standards for 4 racial/ethnic groups of fetuses and 2) to identify factors associated with decrements in expected fetal growth. Related goals are in developing algorithms for better estimating fetal weight and in determining the optimal timing of delivery. A major accomplishment was in the development of a database for the storage of 2D and 3D ultrasonology images and accompanying biometric data. This database is a valuable resource for follow on work aimed at determining specific growth dimensions such as bone length, volumes or organ size. The database for the images is open source software. Successful completion of the study is schedule for September 2014

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7
Fiscal Year
2014
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Indirect Cost
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U.S. National Inst/Child Hlth/Human Dev
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Zhang, Cuilin; Hediger, Mary L; Albert, Paul S et al. (2018) Association of Maternal Obesity With Longitudinal Ultrasonographic Measures of Fetal Growth: Findings From the NICHD Fetal Growth Studies-Singletons. JAMA Pediatr 172:24-31
Grantz, Katherine L; Hediger, Mary L; Liu, Danping et al. (2018) Fetal growth standards: the NICHD fetal growth study approach in context with INTERGROWTH-21st and the World Health Organization Multicentre Growth Reference Study. Am J Obstet Gynecol 218:S641-S655.e28
Pugh, S J; Ortega-Villa, A M; Grobman, W et al. (2018) Estimating gestational age at birth from fundal height and additional anthropometrics: a prospective cohort study. BJOG 125:1397-1404
Buck Louis, Germaine M; Zhai, Shuyan; Smarr, Melissa M et al. (2018) Endocrine disruptors and neonatal anthropometry, NICHD Fetal Growth Studies - Singletons. Environ Int 119:515-526
Grewal, Jagteshwar; Grantz, Katherine L; Zhang, Cuilin et al. (2018) Cohort Profile: NICHD Fetal Growth Studies-Singletons and Twins. Int J Epidemiol 47:25-25l
Bever, Alaina M; Pugh, Sarah J; Kim, Sungduk et al. (2018) Fetal Growth Patterns in Pregnancies With First-Trimester Bleeding. Obstet Gynecol 131:1021-1030
Grantz, Katherine L; Kim, Sungduk; Grobman, William A et al. (2018) Fetal growth velocity: the NICHD fetal growth studies. Am J Obstet Gynecol 219:285.e1-285.e36
Workalemahu, Tsegaselassie; Grantz, Katherine L; Grewal, Jagteshwar et al. (2018) Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy. Sci Rep 8:7274
Elmi, Angelo F; Grantz, Katherine L; Albert, Paul S (2018) An approximate joint model for multiple paired longitudinal outcomes and time-to-event data. Biometrics 74:1112-1119
Ortega-Villa, Ana Maria; Grantz, Katherine L; Albert, Paul S (2018) Estimating onset time from longitudinal and cross-sectional data with an application to estimating gestational age from longitudinal maternal anthropometry during pregnancy and neonatal anthropometry at birth. J R Stat Soc Ser A Stat Soc 181:825-842

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