In the past year investigators and staff on this project developed nonparametric sequential methods for evaluation of diagnostic biomarkers. They investigated a two-stage procedures for selecting the best diagnostic biomarkers to control the probability of incorrect selection. Methods for point and interval estimation of accuracies of a binary diagnostic biomarkers were developed following group sequential evaluation of the biomarkers' sensitivity and specificity. For biomarkers whose measurements are subject to limits of detection, the group developed maximum likelihood ratio tests for comparing the discriminatory ability of biomarkers subject to limit of detection. To design comparative diagnostic accuracy studies an adaptive approach was developed to maintain the study power due to misspecifications of nuisance parameters.

Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2015
Total Cost
Indirect Cost
Name
U.S. National Inst/Child Hlth/Human Dev
Department
Type
DUNS #
City
State
Country
Zip Code
Gee, B T; Nansel, T R; Liu, A (2017) Reduction of hypoglycaemic events with a behavioural intervention: a randomized clinical trial for paediatric patients with Type 1 diabetes mellitus. Diabet Med 34:340-347
Yin, Lixuan; Diao, Guoqing; Liu, Aiyi (2017) A semiparametric method for comparing the discriminatory ability of biomarkers subject to limit of detection. Stat Med 36:4141-4152
Zhang, Wei; Yang, Liu; Tang, Larry L et al. (2017) GATE: an efficient procedure in study of pleiotropic genetic associations. BMC Genomics 18:552
Nansel, Tonja R; Lipsky, Leah M; Liu, Aiyi (2016) Greater diet quality is associated with more optimal glycemic control in a longitudinal study of youth with type 1 diabetes. Am J Clin Nutr 104:81-7
Wu, Mixia; Zhang, Dianchen; Liu, Aiyi (2016) Estimation of an accuracy index of a diagnostic biomarker when the reference biomarker is continuous and measured with error. J Biopharm Stat 26:1111-1117
Li, Shanshan; Zhu, Yeyi; Chavarro, Jorge E et al. (2016) Healthful Dietary Patterns and the Risk of Hypertension Among Women With a History of Gestational Diabetes Mellitus: A Prospective Cohort Study. Hypertension 67:1157-65
Liu, Aiyi; Yue, Lilly Q (2016) A conversation with Dr. Greg Campbell. J Biopharm Stat 26:1007-1019
Lipsky, Leah M; Gee, Benjamin; Liu, Aiyi et al. (2016) Glycemic control and variability in association with body mass index and body composition over 18months in youth with type 1 diabetes. Diabetes Res Clin Pract 120:97-103
Boghossian, Nansi S; Sicko, Robert J; Kay, Denise M et al. (2016) Rare copy number variants implicated in posterior urethral valves. Am J Med Genet A 170:622-33
Kang, Le; Liu, Aiyi; Tian, Lili (2016) Linear combination methods to improve diagnostic/prognostic accuracy on future observations. Stat Methods Med Res 25:1359-80

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