Abstract

In the past year, we have made several new transgenic mice lines. We made for the first time, using Zinc fingers, apoC-II KO mice to investigate the effect of an apoC-II mimetic peptide that we have developed for lowering serum triglycerides. This mouse also had an unexpected obesity and insulin resistance phenotype, which we plan to investigate in the future. Produced a novel mouse model of over expression of SR-BI in endothelial cells, which protected against diet induced atherosclerosis and was just accepted for publication. Crossed our SR-BI-KO mice with mice either over or under expressing LCAT transgenic mice and showed a positive benefit of increased LCAT activity in reducing diet induced atherosclerosis, which was just accepted for publication.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAHL002058-20
Application #
9157320
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
20
Fiscal Year
2015
Total Cost
Indirect Cost

  Institution

Name
U.S. National Heart Lung and Blood Inst
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Li, Dan; Fawaz, Maria V; Morin, Emily E et al. (2018) Effect of Synthetic High Density Lipoproteins Modification with Polyethylene Glycol on Pharmacokinetics and Pharmacodynamics. Mol Pharm 15:83-96
Liu, Yudong; Carmona-Rivera, Carmelo; Moore, Erica et al. (2018) Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis. Front Immunol 9:1680
Liu, Chao; Han, Tianxu; Stachura, David L et al. (2018) Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. Nat Commun 9:1310
Yang, Zhi-Hong; Gordon, Scott M; Sviridov, Denis et al. (2017) Dietary supplementation with long-chain monounsaturated fatty acid isomers decreases atherosclerosis and alters lipoprotein proteomes in LDLr(-/-) mice. Atherosclerosis 262:31-38
Baranova, Irina N; Souza, Ana C P; Bocharov, Alexander V et al. (2017) Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo. PLoS One 12:e0175824
Couchie, Dominique; Vaisman, Boris; Abderrazak, Amna et al. (2017) Human Plasma Thioredoxin-80 Increases With Age and in ApoE-/- Mice Induces Inflammation, Angiogenesis, and Atherosclerosis. Circulation 136:464-475
Gordon, Scott M; Remaley, Alan T (2017) High density lipoproteins are modulators of protease activity: Implications in inflammation, complement activation, and atherothrombosis. Atherosclerosis 259:104-113
Furumoto, Yasuko; Smith, Carolyne K; Blanco, Luz et al. (2017) Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction. Arthritis Rheumatol 69:148-160
Sakurai, Toshihiro; Sakurai, Akiko; Chen, Ye et al. (2017) Dietary ?-cyclodextrin reduces atherosclerosis and modifies gut flora in apolipoprotein E-deficient mice. Mol Nutr Food Res 61:
Ahmad, Faiyaz; Chung, Youn Wook; Tang, Yan et al. (2016) Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue. Sci Rep 6:28056

Showing the most recent 10 out of 46 publications