Abstract

In the past year, we have continued to use both commercially available and unique mouse strains that we have developed to investigate the association between lipoprotein metabolism and atherosclerosis. We have completed and published several studies on novel fatty acids and or the addition of aspirin to an omega3-rich diets on atherosclerosis, using mouse models. In addition, we showed that oral alpha-cyclodextrin by changing the gut flora had a marked effect in reducing atherosclerosis in ApoE-KO mice. Recently we have also created a novel knockout mouse for DennD5b, which we identified in a phage display screen, and showed that it is involved in the secretion of vesicles containing chylomicrons in the small intestine.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAHL002058-22
Application #
9554426
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
22
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
U.S. National Heart Lung and Blood Inst
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Liu, Chao; Han, Tianxu; Stachura, David L et al. (2018) Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. Nat Commun 9:1310
Li, Dan; Fawaz, Maria V; Morin, Emily E et al. (2018) Effect of Synthetic High Density Lipoproteins Modification with Polyethylene Glycol on Pharmacokinetics and Pharmacodynamics. Mol Pharm 15:83-96
Liu, Yudong; Carmona-Rivera, Carmelo; Moore, Erica et al. (2018) Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis. Front Immunol 9:1680
Yang, Zhi-Hong; Gordon, Scott M; Sviridov, Denis et al. (2017) Dietary supplementation with long-chain monounsaturated fatty acid isomers decreases atherosclerosis and alters lipoprotein proteomes in LDLr(-/-) mice. Atherosclerosis 262:31-38
Baranova, Irina N; Souza, Ana C P; Bocharov, Alexander V et al. (2017) Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo. PLoS One 12:e0175824
Couchie, Dominique; Vaisman, Boris; Abderrazak, Amna et al. (2017) Human Plasma Thioredoxin-80 Increases With Age and in ApoE-/- Mice Induces Inflammation, Angiogenesis, and Atherosclerosis. Circulation 136:464-475
Gordon, Scott M; Remaley, Alan T (2017) High density lipoproteins are modulators of protease activity: Implications in inflammation, complement activation, and atherothrombosis. Atherosclerosis 259:104-113
Furumoto, Yasuko; Smith, Carolyne K; Blanco, Luz et al. (2017) Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction. Arthritis Rheumatol 69:148-160
Sakurai, Toshihiro; Sakurai, Akiko; Chen, Ye et al. (2017) Dietary ?-cyclodextrin reduces atherosclerosis and modifies gut flora in apolipoprotein E-deficient mice. Mol Nutr Food Res 61:
Ahmad, Faiyaz; Chung, Youn Wook; Tang, Yan et al. (2016) Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue. Sci Rep 6:28056

Showing the most recent 10 out of 46 publications