We showed that our fast x-ray phase-contrast dark-field imaging techniques can be used in live animals, and developed two-dimensional versions for improved image quality. We focused on the fabrication of a new type of nano scale x-ray grating for the next generation of phase-contrast radiography and CT machines. Such gratings are the key element in realizing the dramatic enhancement in soft tissue contrast and radiation dose reduction promised by phase-contrast x-ray imaging. In the area of diffusion MRI we are able to adapt our new image processing technology to cardiac diffusion MRI in acute CAD patients and demonstrate correlative results with contrast-agent assisted images that localize the areas of tissue injury in the heart.

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National Heart, Lung, and Blood Institute
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George, Alex; Chen, Peter Y; Morales-Martinez, Alejandro et al. (2017) Geometric calibration and correction for a lens-coupled detector in x-ray phase-contrast imaging. J Med Imaging (Bellingham) 4:013507
Miao, Houxun; Chen, Lei; Mirzaeimoghri, Mona et al. (2016) Cryogenic Etching of High Aspect Ratio 400 nm Pitch Silicon Gratings. J Microelectromech Syst 25:963-967
Miao, Houxun; Panna, Alireza; Gomella, Andrew A et al. (2016) A Universal Moiré Effect and Application in X-Ray Phase-Contrast Imaging. Nat Phys 12:830-834
Miao, Houxun; Gomella, Andrew A; Harmon, Katherine J et al. (2015) Enhancing Tabletop X-Ray Phase Contrast Imaging with Nano-Fabrication. Sci Rep 5:13581
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Harmon, Katherine J; Miao, Houxun; Gomella, Andrew A et al. (2015) Motionless electromagnetic phase stepping versus mechanical phase stepping in x-ray phase-contrast imaging with a compact source. Phys Med Biol 60:3031-43
Harmon, Katherine J; Bennett, Eric E; Gomella, Andrew A et al. (2014) Efficient decoding of 2D structured illumination with linear phase stepping in X-ray phase contrast and dark-field imaging. PLoS One 9:e87127
Wen, Han; Gomella, Andrew A; Patel, Ajay et al. (2014) Boosting phase contrast with a grating Bonse-Hart interferometer of 200 nanometre grating period. Philos Trans A Math Phys Eng Sci 372:20130028
Miao, Houxun; Gomella, Andrew A; Chedid, Nicholas et al. (2014) Fabrication of 200 nm period hard X-ray phase gratings. Nano Lett 14:3453-8
Wen, Han; Wolfe, Douglas E; Gomella, Andrew A et al. (2013) Interferometric hard x-ray phase contrast imaging at 204 nm grating period. Rev Sci Instrum 84:013706

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