In collaboration with the NHLBI EM Core and Dr. Kenneth Olivier, we have been acquiring high-resolution 3D data of human nasal cell specimens which are used to guide EM studies. We also acquired sub-micron resolution x-ray 3D data in collaboration with APS of Argonne National Laboratory. We are in the process of developing faster x-ray tomosythesis techniques for short time windows, such as for cryo-samples. We are also interested in x-ray micro-tomosynthesis as part of a collaboration with Dr. Priya Bhandarkar of Walter Reed NMMC for specimen studies. The tomosynthesis system is built, while processing software needs to be built.

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Support Year
5
Fiscal Year
2015
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Indirect Cost
Name
U.S. National Heart Lung and Blood Inst
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Wen, Han; Morales Martinez, Alejandro; Miao, Houxun et al. (2018) Correlative Detection of Isolated Single and Multi-Cellular Calcifications in the Internal Elastic Lamina of Human Coronary Artery Samples. Sci Rep 8:10978
Larsen, Thomas C; Gopalakrishnan, Vissagan; Yao, Jianhua et al. (2018) Optimization of a secondary VOI protocol for lung imaging in a clinical CT scanner. J Appl Clin Med Phys 19:271-280
Morales, A G; Stempinski, E S; Xiao, X et al. (2016) Micro-CT scouting for transmission electron microscopy of human tissue specimens. J Microsc 263:113-7
Gomella, Andrew; Martin, Eric W; Lynch, Susanna K et al. (2013) Low dose hard x-ray contact microscopy assisted by a photoelectric conversion layer. AIP Adv 3:42121