In collaboration with the NHLBI Pathology and EM Cores we have developed a prototype x-ray scanner to provide high resolution scout images of pathology specimens to guide the sectioning and histologic imaging of the specimens. In collaboration with Drs. Marcus Chen and Joel Moss we are working on high-resolution CT technology to enhance the level of detail in diagnostic CT scans in order to reduce the need of invasive procedures such as biopsy. In collaboration with Don Devoe of University of Maryland, we are exploring micro 3D printing technology to make polymer based hard x-ray optics that may have benchtop microscopy applications.

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Support Year
7
Fiscal Year
2017
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U.S. National Heart Lung and Blood Inst
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Wen, Han; Morales Martinez, Alejandro; Miao, Houxun et al. (2018) Correlative Detection of Isolated Single and Multi-Cellular Calcifications in the Internal Elastic Lamina of Human Coronary Artery Samples. Sci Rep 8:10978
Larsen, Thomas C; Gopalakrishnan, Vissagan; Yao, Jianhua et al. (2018) Optimization of a secondary VOI protocol for lung imaging in a clinical CT scanner. J Appl Clin Med Phys 19:271-280
Morales, A G; Stempinski, E S; Xiao, X et al. (2016) Micro-CT scouting for transmission electron microscopy of human tissue specimens. J Microsc 263:113-7
Gomella, Andrew; Martin, Eric W; Lynch, Susanna K et al. (2013) Low dose hard x-ray contact microscopy assisted by a photoelectric conversion layer. AIP Adv 3:42121