The goal of this collaboration is to follow up on recent discoveries to exploit a critical protein-protein interaction in B. burgdorferi that dictates infectivity of Lyme disease agents to identify small molecule inhibitors of this interaction. During this period, the project team worked to optimize and miniaturize the B. burgdorferi protein-protein interaction assay to eventually enable quantitative high-throughput screening. Future efforts are intended to include completion of the full qHTS screen of a selection of NCGC's small molecule libraries, following by hit validation, activity profiling, and eventually advancement toward medicinal chemistry optimization of select hit molecules.

Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2019
Total Cost
Indirect Cost
Name
National Center for Advancing Translational Sciences
Department
Type
DUNS #
City
State
Country
Zip Code