The Clinical Research Core is responsible for processing human samples from numerous clinical studies currently in progress. Once the samples are acquired we process it according to the instructions on the protocol, aliquot, label and store the samples for the various principal investigators as per their instructions. We are currently processing an average of 986 samples/week. All samples processed in the lab are set up with a tracking number and entered into a database which is maintained by the Core lab. Studies that have started since January 2008 are labeled using a 2D-barcode system. In addition to the biorepository needs of the PIs, the Clinical Research Core also provides assay services for analyses which are currently not available at DLM. We have tested and validated numerous methods to measure total and active Glucagon-like Peptide-1, Acyl Ghrelin, Desacyl Ghrelin, Leptin, Adiponectin, Oxyntomodulin and several other markers in human plasma.

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Brown, Rebecca J; Valencia, Areli; Startzell, Megan et al. (2018) Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy. J Clin Invest 128:3504-3516
Blau, Jenny E; Bauman, Viviana; Conway, Ellen M et al. (2018) Canagliflozin triggers the FGF23/1,25-dihydroxyvitamin D/PTH axis in healthy volunteers in a randomized crossover study. JCI Insight 3:
Begaye, Brittany; Piaggi, Paolo; Thearle, Marie S et al. (2018) Norepinephrine and T4 Are Predictors of Fat Mass Gain in Humans With Cold-Induced Brown Adipose Tissue Activation. J Clin Endocrinol Metab 103:2689-2697
Muniyappa, Ranganath; Abel, Brent S; Asthana, Asha et al. (2017) Metreleptin therapy lowers plasma angiopoietin-like protein 3 in patients with generalized lipodystrophy. J Clin Lipidol 11:543-550
Glicksman, Michael; Asthana, Asha; Abel, Brent S et al. (2017) Plasma serpinB1 is related to insulin sensitivity but not pancreatic ?-Cell function in non-diabetic adults. Physiol Rep 5:
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Brown, Rebecca J; Meehan, Cristina Adelia; Cochran, Elaine et al. (2017) Effects of Metreleptin in Pediatric Patients With Lipodystrophy. J Clin Endocrinol Metab 102:1511-1519
Fothergill, Erin; Guo, Juen; Howard, Lilian et al. (2016) Persistent metabolic adaptation 6 years after ""The Biggest Loser"" competition. Obesity (Silver Spring) 24:1612-9
Sylvetsky, Allison C; Brown, Rebecca J; Blau, Jenny E et al. (2016) Hormonal responses to non-nutritive sweeteners in water and diet soda. Nutr Metab (Lond) 13:71
Muniyappa, Ranganath; Noureldin, Radwa; Ouwerkerk, Ronald et al. (2015) Myocardial Fat Accumulation Is Independent of Measures of Insulin Sensitivity. J Clin Endocrinol Metab 100:3060-8

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