The clinical core isotope ratio mass spectrometry (IRMS) core laboratory was started to support all stable isotope applications in the clinical labs. Two isotope ratio mass spectrometers were installed in February 2009. One system can measure the isotope ratios of oxygen and hydrogen in water for energy expenditure applications. Methods for oxygen and hydrogen isotopic measurements have been developed and validated. Research has progressed towards the analysis of minute samples that may be able to analyze samples from animal studies. The second system is a GC-IRMS for metabolic studies. Initial metabolic studies will include labeled glucose, this method is currently under investigation.
| Baskin, Alison S; Linderman, Joyce D; Brychta, Robert J et al. (2018) Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a ?3-Adrenergic Receptor Agonist. Diabetes 67:2113-2125 |
| Rother, Kristina I; Sylvetsky, Allison C; Walter, Peter J et al. (2018) Pharmacokinetics of Sucralose and Acesulfame-Potassium in Breast Milk Following Ingestion of Diet Soda. J Pediatr Gastroenterol Nutr 66:466-470 |
| Brown, Rebecca J; Valencia, Areli; Startzell, Megan et al. (2018) Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy. J Clin Invest 128:3504-3516 |
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| Carmona-Rivera, Carmelo; Purmalek, Monica M; Moore, Erica et al. (2017) A role for muscarinic receptors in neutrophil extracellular trap formation and levamisole-induced autoimmunity. JCI Insight 2:e89780 |
| Kerns, Jennifer C; Guo, Juen; Fothergill, Erin et al. (2017) Increased Physical Activity Associated with Less Weight Regain Six Years After ""The Biggest Loser"" Competition. Obesity (Silver Spring) 25:1838-1843 |
| Sylvetsky, Allison C; Bauman, Viviana; Blau, Jenny E et al. (2017) Plasma concentrations of sucralose in children and adults. Toxicol Environ Chem 99:535-542 |
| Fothergill, Erin; Guo, Juen; Howard, Lilian et al. (2016) Persistent metabolic adaptation 6 years after ""The Biggest Loser"" competition. Obesity (Silver Spring) 24:1612-9 |
| Howard, Louisa C; Liu, Chia-Ying; Purdy, Julia B et al. (2016) Lipolytic Rate Associated With Intramyocardial Lipid in an HIV Cohort Without Increased Lipolysis. J Clin Endocrinol Metab 101:151-6 |
| Sylvetsky, Allison C; Gardner, Alexandra L; Bauman, Viviana et al. (2015) Nonnutritive Sweeteners in Breast Milk. J Toxicol Environ Health A 78:1029-32 |
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