The clinical core stable isotope ratio mass spectrometry core laboratory was started to support all stable isotope applications in the clinical labs. In our 1st full year with our 2 IRMS systems installed, there has been tremendous progress. The first clinical doubly labeled water has been completed. Several new DLW studies are underway with Monica Skarulis, Kong Chen and Kevin Hall. Research continues towards analysis of minute samples for DLW studies. Metabolic tracer studies are about to begin. We have been preparing for numerous stable isotope tracer studies. Deuterium and 13-carbon glucose methods have been developed. Kristina Rother, Rebecca Brown, Bernard Miller and Anne Sumner will all be starting glucose tracer studies in the next few months. We developed a method for the analysis of 3-O-methyl glucose for a study that Kristina Rother and Rebecca Brown are starting. We are developing a method for labeled free fatty acids for studies that Bernard Miller and Anne Sumner are planning.

Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2010
Total Cost
$1,009,778
Indirect Cost
City
State
Country
Zip Code
Baskin, Alison S; Linderman, Joyce D; Brychta, Robert J et al. (2018) Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a ?3-Adrenergic Receptor Agonist. Diabetes 67:2113-2125
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Howard, Louisa C; Liu, Chia-Ying; Purdy, Julia B et al. (2016) Lipolytic Rate Associated With Intramyocardial Lipid in an HIV Cohort Without Increased Lipolysis. J Clin Endocrinol Metab 101:151-6
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