Clinical Support Services for the NIAMS Intramural Research Program

Siegel, Richard M.

Abstract

This project has provided research infrastructure support for the following clinical protocols: 91-AR-0196 Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related Diseases 94-AR-0066 Studies of the Pathogenesis and Natural History of Systemic Lupus Erythematosus (SLE) 94-AR-0105 Genetics and Pathophysiology of Familial Mediterranean Fever and Related Disorders 99-D-0070 Natural History of Salivary Gland Dysfunction and Sjogren's Syndrome 00-AR-0222 Studies of the Pathogenesis and Natural History of Arthritis and Related Conditions 01-AR-0227 Natural History of Rheumatic Disease in Minority Communities 02-AR-0156 A Randomized, Double-Blind, Placebo-Controlled Trial of Infliximab in Patients with Dermatomyositis and Polymyositis 03-AR-0130 Genetic Determinants of Ankylosing Spondylitis Severity - Cross Sectional Study 03-AR-0131 Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study 03-AR-0133 Clinically Important Changes in Rheumatoid Arthritis 03-AR-0173 Studies of the Natural History and Pathogenesis of Neonatal Onset Multisystem Inflammatory Disease (NOMID) 03-AR-0298 A Pilot Study of the IL-1 Receptor Antagonist Anakinra/Kineret in Patients with Neonatal Onset Multisystem Inflammatory Disease (NOMID/CINCA Syndrome) 04-AR-0205 Progression of Spinal Fusion in Ankylosing Spondylitis 05-AR-0014 A Pilot Open-Label Study of IL-1 Trap in Adult Subjects with Autoinflammatory Disease: A Therapeutic Approach to Study Pathogenesis 07-E-0012 Rituximab in the Treatment of Refractory Adult and Juvenile Dermatomyositis (DM) and Polymyositis (PM) 08-AR-0008 Insulin Resistance and Atherosclerosis in a Sample of Women with Systemic Lupus Erythematosus 08-AR-0218 Rilonacept to Treat Familial Mediterranean Fever 09-AR-0066 Canakinumab to Treat Neonatal Onset Multisystem Inflammatory Disease

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Type: Clinical Support Services Intramural Research (ZID)
• Project #: 1ZIDAR041180-04
• Application #: 8344993
• Support Year: 4
• Fiscal Year: 2011
• Total Cost: $4,112,106

Institution

• Name: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publications

De Lorenzo, Rebecca; Pinal-Fernandez, Iago; Huang, Wilson et al. (2018) Muscular and extramuscular clinical features of patients with anti-PM/Scl autoantibodies. Neurology 90:e2068-e2076

Jha, Smita; Fratzl-Zelman, Nadja; Roschger, Paul et al. (2018) Distinct clinical and pathological features of melorheostosis associated with somatic MAP2K1 mutations. J Bone Miner Res :

Sanchez, Gina A Montealegre; Reinhardt, Adam; Ramsey, Suzanne et al. (2018) JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies. J Clin Invest 128:3041-3052

Pinal-Fernandez, Iago; Casal-Dominguez, Maria; Mammen, Andrew L (2018) Immune-Mediated Necrotizing Myopathy. Curr Rheumatol Rep 20:21

Sikora, Keith A; Bennett, Joshua R; Vyncke, Laurens et al. (2018) Germline gain-of-function myeloid differentiation primary response gene-88 (MYD88) mutation in a child with severe arthritis. J Allergy Clin Immunol 141:1943-1947.e9

Ward, Michael M; Hu, Jinxiang; Guthrie, Lori C et al. (2018) Testing the construct validity of a health transition question using vignette-guided patient ratings of health. Health Qual Life Outcomes 16:2

Brunham, Liam R; Baker, Steven; Mammen, Andrew et al. (2018) Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence. Cardiovasc Res 114:1073-1081

Barrera-Vargas, Ana; Gómez-Martín, Diana; Carmona-Rivera, Carmelo et al. (2018) Differential ubiquitination in NETs regulates macrophage responses in systemic lupus erythematosus. Ann Rheum Dis 77:944-950

Mistry, Pragnesh; Carmona-Rivera, Carmelo; Ombrello, Amanda K et al. (2018) Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome. Ann Rheum Dis :

Szymanski, Ann Marie; Ombrello, Michael J (2018) Using genes to triangulate the pathophysiology of granulomatous autoinflammatory disease: NOD2, PLCG2 and LACC1. Int Immunol 30:205-213