A number of medical retinal protocols have been conducted at the NEI clinical center. Many are phase 1 studies while others are studies in the screening and evaluation and treatment protocol. These provide patients for screening for trials and epidemiologic studies conducted by the Division of Epidemiology and Clinical Applications. . These include the followup of Age-Related Eye Disease Study (AREDS2) and AREDS2 follow-up, lucentis or avastin (anti-VEGF therapy) for treatment of diabetic macular edema, while lucentis for a study of high speed indocyanine green angiography for age-related macular degeneration, treatment with microglial inhibitors for diabetic retinopathy and retinovascular occlusions, treatments for central serous retinopathy, and genetic studies of age-related macular degeneration. We have also had a biobank protocol where we would collect DNA and blood for a number of retinovascular diseases. We are also beginning a collaboration with the NINDS on evaluating the fundus of patients with Alzheimer's disease.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Clinical Training Intramural Research (ZIE)
Project #
1ZIEEY000487-07
Application #
9155651
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2015
Total Cost
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
Zip Code
Nicholson, Benjamin P; Nigam, Divya; Toy, Brian et al. (2015) Effect of ranibizumab on high-speed indocyanine green angiography and minimum intensity projection optical coherence tomography findings in neovascular age-related macular degeneration. Retina 35:58-68
Chew, Emily Y; Klein, Michael L; Clemons, Traci E et al. (2014) No clinically significant association between CFH and ARMS2 genotypes and response to nutritional supplements: AREDS report number 38. Ophthalmology 121:2173-80
Age-Related Eye Disease Study 2 Research Group; Huynh, Nancy; Nicholson, Benjamin P et al. (2014) Visual acuity after cataract surgery in patients with age-related macular degeneration: age-related eye disease study 2 report number 5. Ophthalmology 121:1229-36
Aronow, Mary E; Chew, Emily Y (2014) Age-related Eye Disease Study 2: perspectives, recommendations, and unanswered questions. Curr Opin Ophthalmol 25:186-90
Chu, Xi K; Meyerle, Catherine B; Liang, Xiaoling et al. (2014) In-depth analyses unveil the association and possible functional involvement of novel RAD51B polymorphisms in age-related macular degeneration. Age (Dordr) 36:9627
Pacak, Karel; Chew, Emily Y; Pappo, Alberto S et al. (2014) Ocular manifestations of hypoxia-inducible factor-2? paraganglioma-somatostatinoma-polycythemia syndrome. Ophthalmology 121:2291-3
Wong, Wai T; Dresner, Samuel; Forooghian, Farzin et al. (2013) Treatment of geographic atrophy with subconjunctival sirolimus: results of a phase I/II clinical trial. Invest Ophthalmol Vis Sci 54:2941-50
Danis, Ronald P; Domalpally, Amitha; Chew, Emily Y et al. (2013) Methods and reproducibility of grading optimized digital color fundus photographs in the Age-Related Eye Disease Study 2 (AREDS2 Report Number 2). Invest Ophthalmol Vis Sci 54:4548-54
Chew, Emily Y; Clemons, Traci E; Agrón, Elvira et al. (2013) Long-term effects of vitamins C and E, ?-carotene, and zinc on age-related macular degeneration: AREDS report no. 35. Ophthalmology 120:1604-11.e4
Meleth, Annal D; Toy, Brian C; Nigam, Divya et al. (2013) Prevalence and progression of pigment clumping associated with idiopathic macular telangiectasia type 2. Retina 33:762-70

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