A number of medical retinal protocols have been conducted at the NEI clinical center. Many are phase 1 studies while others are studies in the screening and evaluation and treatment protocol. These provide patients for screening for trials and epidemiologic studies conducted by the Division of Epidemiology and Clinical Applications. These include the followup of Age-Related Eye Disease Study (AREDS2) and AREDS2 follow-up, studies of dark adaptation in patients with AMD, treatment with microglial inhibitors for diabetic retinopathy and retinovascular occlusions, treatments for central serous retinopathy, and genetic studies of age-related macular degeneration, and genetic studies of patients with hydroxychloroquine induced toxicity. We have also had a biobank protocol where we would collect DNA and blood for a number of retinovascular diseases. We are also beginning a collaboration with NINDS on HIV ocular findings in those with HIV associated neurodegeneration, with NHGRI in patinets in the Clinseq protocol and NCI in patients with VHL.

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National Eye Institute (NEI)
Clinical Training Intramural Research (ZIE)
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Nicholson, Benjamin P; Nigam, Divya; Toy, Brian et al. (2015) Effect of ranibizumab on high-speed indocyanine green angiography and minimum intensity projection optical coherence tomography findings in neovascular age-related macular degeneration. Retina 35:58-68
Chew, Emily Y; Klein, Michael L; Clemons, Traci E et al. (2014) No clinically significant association between CFH and ARMS2 genotypes and response to nutritional supplements: AREDS report number 38. Ophthalmology 121:2173-80
Age-Related Eye Disease Study 2 Research Group; Huynh, Nancy; Nicholson, Benjamin P et al. (2014) Visual acuity after cataract surgery in patients with age-related macular degeneration: age-related eye disease study 2 report number 5. Ophthalmology 121:1229-36
Aronow, Mary E; Chew, Emily Y (2014) Age-related Eye Disease Study 2: perspectives, recommendations, and unanswered questions. Curr Opin Ophthalmol 25:186-90
Chu, Xi K; Meyerle, Catherine B; Liang, Xiaoling et al. (2014) In-depth analyses unveil the association and possible functional involvement of novel RAD51B polymorphisms in age-related macular degeneration. Age (Dordr) 36:9627
Pacak, Karel; Chew, Emily Y; Pappo, Alberto S et al. (2014) Ocular manifestations of hypoxia-inducible factor-2? paraganglioma-somatostatinoma-polycythemia syndrome. Ophthalmology 121:2291-3
Ratnapriya, R; Chew, E Y (2013) Age-related macular degeneration-clinical review and genetics update. Clin Genet 84:160-6
Dalal, Monica; Jacobs-El, Naima; Nicholson, Benjamin et al. (2013) Subconjunctival Palomid 529 in the treatment of neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 251:2705-9
Domalpally, Amitha; Danis, Ronald P; Chew, Emily Y et al. (2013) Evaluation of optimized digital fundus reflex photographs for lens opacities in the age-related eye disease study 2: AREDS2 report 7. Invest Ophthalmol Vis Sci 54:5989-94
Wong, Wai T; Dresner, Samuel; Forooghian, Farzin et al. (2013) Treatment of geographic atrophy with subconjunctival sirolimus: results of a phase I/II clinical trial. Invest Ophthalmol Vis Sci 54:2941-50

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