The W.D. Miller General Clinical Research Center has been established to facilitate clinical investigations in oral disease, oral health assessment, and dental care delivery. During the past year, the primary objective of the center has been to bring together multidisciplinary teams of University researchers, trained staff and project-related personnel in order to provide an optimal environment for the implementation of controlled clinical trials. Clinical and basic scientists from the School of Dental Medicine have collaborated with researchers at the Monell Chemical Senses Center, Childrens Hospital of Philadelphia and the Department of Bioengineering and Hospital of the University of Penn through the GCRC in their efforts to understand the etiology progression, methods of prevention, control and cure of various oral disease processes. Research activities conducted through the Center have been co-ordinated to maximize the use of financial, physical and human resources. The collection of specimens (i.e., saliva, serum, plaque) from individual subjects for multiple investigations has functioned as an efficient method of project implementation. Through this centralized service and facility, the W.D. Miller GCRC has assisted investigators in research design and procurement of funding, accessed and maintained human subject populations, performed required patient procedures as specified in study protocols, stored specimens and carried out routine laboratory procedures, developed complex statistical and computer programs for data analysis and management and assisted in the analysis, interpretation and dissemination of results.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR001224-09
Application #
3090257
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
1979-10-01
Project End
1989-11-30
Budget Start
1986-12-01
Budget End
1987-11-30
Support Year
9
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Dentistry/Oral Hygn
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Rams, T E; Listgarten, M A; Slots, J (2006) Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis subgingival presence, species-specific serum immunoglobulin G antibody levels, and periodontitis disease recurrence. J Periodontal Res 41:228-34
Pan, J W; Kim, J H; Cohen-Gadol, A et al. (2005) Regional energetic dysfunction in hippocampal epilepsy. Acta Neurol Scand 111:218-24
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Rams, T E; Listgarten, M A; Slots, J (1996) Efficacy of CPITN sextant scores for detection of periodontitis disease activity. J Clin Periodontol 23:355-61
Rams, T E; Listgarten, M A; Slots, J (1996) Utility of 5 major putative periodontal pathogens and selected clinical parameters to predict periodontal breakdown in patients on maintenance care. J Clin Periodontol 23:346-54
Navazesh, M; Wood, G J; Brightman, V J (1995) Relationship between salivary flow rates and Candida albicans counts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 80:284-8
DiRienzo, J M; McKay, T L (1994) Identification and characterization of genetic cluster groups of Actinobacillus actinomycetemcomitans isolated from the human oral cavity. J Clin Microbiol 32:75-81
DiRienzo, J M; Slots, J; Sixou, M et al. (1994) Specific genetic variants of Actinobacillus actinomycetemcomitans correlate with disease and health in a regional population of families with localized juvenile periodontitis. Infect Immun 62:3058-65
Rams, T E; Listgarten, M A; Slots, J (1994) Utility of radiographic crestal lamina dura for predicting periodontitis disease-activity. J Clin Periodontol 21:571-6
Ghafari, J; Jacobsson-Hunt, U; Markowitz, D L et al. (1994) Changes of arch width in the early treatment of Class II, division 1 malocclusions. Am J Orthod Dentofacial Orthop 106:496-502

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