Abstract

The project is a prospective, interdisciplinary, longitudinal study of senile dementia of the Alzheimer type (SDAT).
The aim i s the correlation of clinical and autopsy findings. The diagnosis will be established on clinical grounds after eliminating other possible causes. Extensive physical, neurologic, radiologic, neuropsychologic, and language testing will be completed at the first encounter with subsequent updating of these data at regular, usually six-month, intervals. Suitable control population will be selectively studied for comparison. Autopsy material derived from this group will have neuropathologic, immunohistochemical studies for hormones and peptides, neurotransmitter, and quantitative neuron examinations. This longitudinal study during life with subsequent autopsy study will provide information regarding the taxonomy of the disease, subgroups, clinical course, relationship of various behavioral or language disorders with regional or system involvement, compensation and decompensation mechanisms in the nervous system, and survival predictions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG003644-03
Application #
3090692
Study Section
Aging Review Committee (AGE)
Project Start
1984-04-01
Project End
1987-12-31
Budget Start
1986-04-01
Budget End
1987-12-31
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Rochester
Department
Type
School of Medicine & Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Slemmon, J R; Wengenack, T M; Flood, D G (1997) Profiling of endogenous peptides as a tool for studying development and neurological disease. Biopolymers 43:157-70
Kazee, A M; Cox, C; Richfield, E K (1995) Substantia nigra lesions in Alzheimer disease and normal aging. Alzheimer Dis Assoc Disord 9:61-7
Maguire-Zeiss, K A; Li, Z W; Shimoda, L M et al. (1995) Calbindin D28k mRNA in hippocampus, superior temporal gyrus and cerebellum: comparison between control and Alzheimer disease subjects. Brain Res Mol Brain Res 30:362-6
Wetzel, D M; Bohn, M C; Kazee, A M et al. (1995) Glucocorticoid receptor mRNA in Alzheimer's diseased hippocampus. Brain Res 679:72-81
Flood, D G (1994) Thoughts on no neocortical neuronal loss but loss of volume in AD. Neurobiol Aging 15:363-5;discussion 379-80
Slemmon, J R; Hughes, C M; Campbell, G A et al. (1994) Increased levels of hemoglobin-derived and other peptides in Alzheimer's disease cerebellum. J Neurosci 14:2225-35
Wetzel, D M; Bohn, M C; Hamill, R W (1994) Postmortem stability of mRNA for glucocorticoid and mineralocorticoid receptor in rodent brain. Brain Res 649:117-21
Jette, N; Cole, M S; Fahnestock, M (1994) NGF mRNA is not decreased in frontal cortex from Alzheimer's disease patients. Brain Res Mol Brain Res 25:242-50
Benesch, C G; McDaniel, K D; Cox, C et al. (1993) End-stage Alzheimer's disease. Glasgow Coma Scale and the neurologic examination. Arch Neurol 50:1309-15
Kazee, A M; Eskin, T A; Lapham, L W et al. (1993) Clinicopathologic correlates in Alzheimer disease: assessment of clinical and pathologic diagnostic criteria. Alzheimer Dis Assoc Disord 7:152-64

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