The Skin Phenotyping Core of the Skin Disease Research Center provides a wide array of histological,immunohistochemical, and molecular-based tools to characterize gross and microscopic morphology,functional features and gene expression in skin of mutant and genetically engineered laboratory animals.Special technical expertise within this core includes extensive knowledge of skin and hair follicle morphologyessential for understanding the genotype/phenotype correlations; state of the art methods for geneexpression studies at both mRNA and protein level specifically designed for mouse and human skin; andpossession of a battery of original experimental approaches to the study of skin physiology in vivo. The Corewill assist Center investigators as well as other researchers at Columbia in evaluating the significance of aphenotypic manifestation or unanticipated skin effects of a genetic mutation, drug, or other experimentalmanipulation; to understand the possible functions of genes and molecular pathways implicated in skin/hairphenotype development and to analyze skin expression patterns of genes of investigator's interest at themRNA and protein level using immunohistochemistry and in situ hybridization. In addition, the Core willprovide investigators with proof reading of and suggestions for Materials & Methods sections for publicationsand applications for extramural research funding utilizing skin phenotype analysis. The Skin PhenotypingCore also serves as a center of communication between investigators providing the ground for exchange ofsamples, antibodies, techniques and ideas. The Core brings investigators working in similar projects andtechniques together thus reducing the costs and increasing efficiency of research.
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