- OVERALL Building on a 26-year history, the Environmental Health Sciences Research Center (EHSRC) will advance and translate cutting edge research that addresses environmental health problems across the urban-rural continuum. Rural America faces unique environmental challenges from exposures to farm chemicals, air and water pollution from livestock and agricultural production, rural manufacturing, and the green energy economy. The EHSRC is at the forefront of research in rural environmental health, determining the role of the microbiome in environmental lung disease; elucidating novel pathways of oxidative stress and innate immunity; investigating epigenetic mechanisms of cell alterations; discovering therapeutic modalities to treat environmental disease; and characterizing adverse outcome pathways of engineered nanomaterials, pesticides and other xenobiotics. The EHSRC vision is to be the primary environmental health sciences (EHS) resource for improving the health of rural residents by stimulating and translating innovative EHS research. This is accomplished by gaining new insights into rural exposures; population health; susceptibilities; and pathways of toxicity and repair; and then translating these insights to medicine, public health practice and regulatory policy. Center goals are to: 1) Develop, support and expand innovative interdisciplinary EHS research in key Thematic Areas; 2) Recruit, mentor and nurture talented new and mid-level investigators in EHS; and 3) Engage with communities and policy makers to translate research findings toward improving the health and environment of rural people in the Midwest and the nation. The interdisciplinary research of the EHSRC is organized around Thematic Areas which are: Inflammation and Innate Immunity, Oxidative Stress and Metabolism, Nanotoxicology, and Environmental Disease and Population Health. Three EHSRC facility cores: Integrative Health Sciences Facility, Pulmonary Toxicology Facility, and Environmental Modeling & Exposure Assessment Facility, provide cutting edge services, state-of-the-art equipment and support the authentication of key biological and chemical resources. An Administrative Core provides transformative leadership, leverages institutional support and manages highly effective Pilot Grant and Career Development Programs that provide resources and mentoring to advance the careers of promising and diverse young investigators. The Community Outreach and Engagement Core engages stakeholders in multidirectional communications to ensure relevance of EHSRC research and to translate research findings to environmental public health. Lastly, the EHSRC responds to environmental disasters disseminating accurate and timely information and collecting real-time data on the severity of the disaster and effectiveness of the response.

Public Health Relevance

- OVERALL The Environmental Health Sciences Research Center (EHSRC) is the primary environmental health sciences resource for improving the health of rural residents by stimulating and translating innovative research. This is accomplished by supporting original research addressing rural exposures; population health; susceptibilities; and pathways of toxicity and repair; and then translating this knowledge to medicine, public health practice and regulatory policy. The EHSRC supports four thematic areas which serve as intellectual hubs, three research facility cores, a Pilot Grant Program, a Career Development Program and a Community Outreach and Engagement Core.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES005605-28
Application #
9478765
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Thompson, Claudia L
Project Start
1997-04-01
Project End
2022-03-31
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
28
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Iowa
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Poudel, Barun; Gurung, Prajwal (2018) Allergic asthma: RIPK2 takes the lead. J Leukoc Biol 104:441-443
Uwimana, Eric; Li, Xueshu; Lehmler, Hans-Joachim (2018) Human Liver Microsomes Atropselectively Metabolize 2,2',3,4',6-Pentachlorobiphenyl (PCB 91) to a 1,2-Shift Product as the Major Metabolite. Environ Sci Technol 52:6000-6008
Lynch, Thomas J; Anderson, Preston J; Rotti, Pavana G et al. (2018) Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell 22:653-667.e5
Chen, Zhongxue; Lu, Yan; Lin, Tong et al. (2018) Gene-based genetic association test with adaptive optimal weights. Genet Epidemiol 42:95-103
Lane-Cordova, Abbi D; Kalil, Graziela Z; Wagner, Christopher J et al. (2018) Hemoglobin A1c and C-reactive protein are independently associated with blunted nocturnal blood pressure dipping in obesity-related prediabetes. Hypertens Res 41:33-38
Gray, Robert D; Hardisty, Gareth; Regan, Kate H et al. (2018) Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis. Thorax 73:134-144
Ebeid, Kareem; Meng, Xiangbing; Thiel, Kristina W et al. (2018) Synthetically lethal nanoparticles for treatment of endometrial cancer. Nat Nanotechnol 13:72-81
Herkert, Nicholas J; Spak, Scott N; Smith, Austen et al. (2018) Calibration and evaluation of PUF-PAS sampling rates across the Global Atmospheric Passive Sampling (GAPS) network. Environ Sci Process Impacts 20:210-219
Fisher, Sarah C; Van Zutphen, Alissa R; Romitti, Paul A et al. (2018) Maternal Hypertension, Antihypertensive Medication Use, and Small for Gestational Age Births in the National Birth Defects Prevention Study, 1997-2011. Matern Child Health J 22:237-246
Dhakal, Kiran; Gadupudi, Gopi S; Lehmler, Hans-Joachim et al. (2018) Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs). Environ Sci Pollut Res Int 25:16277-16290

Showing the most recent 10 out of 1123 publications