This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Technological developments for the implementation of High-throughput X-ray Absorption Spectroscopy (HTXAS) have been initiated, as proposed in the grant submission. These developments will include the automation and streamlining of beam line alignment, sample alignment, data acquisition strategies, data acquisition and analysis. The developements are targeted for the general user community as well as for the extension of structural genomics efforts by incorporation of x-ray absorption spectroscopy as a complementary tool to protein crystallography. Feasibility studies to assess sample holder alternatives have been performed. A draft of a comprehensive design document has been completed and prioritization and assignment of tasks has been accomplished. Prof. Scott, who is spending a sabbatical leave at SSRL, is leading the project.
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