The objectives of this study are to understand the organization of synaptic contacts in the retina and the biochemical mechanisms underlying synaptic neurotransmission. Specific projects presently ongoing or planned for the next five years include: 1) An electron microscopic analysis of the synaptic organization of amino acid-accumulating and peptide-containing amacrine cells in the rabbit retina. 2) A biochemical study of dopamine-dependent adenylate cyclase activity and dopamine-dependent protein phosphorylation in isolated carp horizontal cells. 3) A biochemical study of vasoactive intestinal peptide (VIP) stimulation of cyclic AMP accumulation in the carp retina. 4) A combined anatomical and biochemical study of carp horizontal cells maintained in cell culture. 5) A biochemical study of the properties of the dopamine receptors on isolated carp horizontal cells and the antigenic properties of isolated carp horizontal cells.
| Wasfy, Meagan M; Matsui, Jonathan I; Miller, Jessica et al. (2014) myosin 7aa(-/-) mutant zebrafish show mild photoreceptor degeneration and reduced electroretinographic responses. Exp Eye Res 122:65-76 |
| Moyano, Miguel; Porteros, Angel; Dowling, John E (2013) The effects of nicotine on cone and rod b-wave responses in larval zebrafish. Vis Neurosci 30:141-5 |
| Le, Hong-Gam T; Dowling, John E; Cameron, D Joshua (2012) Early retinoic acid deprivation in developing zebrafish results in microphthalmia. Vis Neurosci 29:219-28 |
| Li, Yong N; Tsujimura, Taro; Kawamura, Shoji et al. (2012) Bipolar cell-photoreceptor connectivity in the zebrafish (Danio rerio) retina. J Comp Neurol 520:3786-802 |
| Hensley, Monica R; Emran, Farida; Bonilla, Sylvia et al. (2011) Cellular expression of Smarca4 (Brg1)-regulated genes in zebrafish retinas. BMC Dev Biol 11:45 |
| Stujenske, Joseph M; Dowling, John E; Emran, Farida (2011) The bugeye mutant zebrafish exhibits visual deficits that arise with the onset of an enlarged eye phenotype. Invest Ophthalmol Vis Sci 52:4200-7 |
| Emran, Farida; Rihel, Jason; Adolph, Alan R et al. (2010) Zebrafish larvae lose vision at night. Proc Natl Acad Sci U S A 107:6034-9 |
| Li, Yong N; Matsui, Jonathan I; Dowling, John E (2009) Specificity of the horizontal cell-photoreceptor connections in the zebrafish (Danio rerio) retina. J Comp Neurol 516:442-53 |
| Emran, Farida; Rihel, Jason; Dowling, John E (2008) A behavioral assay to measure responsiveness of zebrafish to changes in light intensities. J Vis Exp : |
| Kojima, Daisuke; Torii, Masaki; Fukada, Yoshitaka et al. (2008) Differential expression of duplicated VAL-opsin genes in the developing zebrafish. J Neurochem 104:1364-71 |
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