Abstract

? GM 48080 Description ? ? These are fundamental studies of the essential cellular process of genetic translation, emphasizing the origin and mechanism of RNA molecules in this process. The research seeks to create new RNA molecules that carry out the component steps of translation: amino acid activation, aminoacyl-RNA synthesis, peptide extension, coding, and also includes the study of the chiral selectivity of translation. These reactions are of concern to biomedical science because their accurate performance is required for the well-being of every cell, and they also provide therapeutic points of attack within pathogenic cells. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM048080-13
Application #
7173310
Study Section
Genetic Variation and Evolution Study Section (GVE)
Program Officer
Rhoades, Marcus M
Project Start
1993-05-01
Project End
2010-01-31
Budget Start
2007-02-01
Budget End
2008-01-31
Support Year
13
Fiscal Year
2007
Total Cost
$272,269
Indirect Cost

  Institution

Name
University of Colorado at Boulder
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
007431505
City
Boulder
State
CO
Country
United States
Zip Code
80309

  Publications

Yarus, Michael (2017) The Genetic Code and RNA-Amino Acid Affinities. Life (Basel) 7:
Turk-Macleod, Rebecca M; Puthenvedu, Deepa; Majerfeld, Irene et al. (2012) The plausibility of RNA-templated peptides: simultaneous RNA affinity for adjacent peptide side chains. J Mol Evol 74:217-25
Turk, Rebecca M; Illangasekare, Mali; Yarus, Michael (2011) Catalyzed and spontaneous reactions on ribozyme ribose. J Am Chem Soc 133:6044-50
Yarus, Michael (2011) Getting past the RNA world: the initial Darwinian ancestor. Cold Spring Harb Perspect Biol 3:
Janas, Teresa; Widmann, Jeremy Joseph; Knight, Rob et al. (2010) Simple, recurring RNA binding sites for L-arginine. RNA 16:805-16
Illangasekare, Mali; Turk, Rebecca; Peterson, G Colin et al. (2010) Chiral histidine selection by D-ribose RNA. RNA 16:2370-83
Majerfeld, Irene; Chocholousova, Jana; Malaiya, Vikas et al. (2010) Nucleotides that are essential but not conserved; a sufficient L-tryptophan site in RNA. RNA 16:1915-24
Turk, Rebecca M; Chumachenko, Nataliya V; Yarus, Michael (2010) Multiple translational products from a five-nucleotide ribozyme. Proc Natl Acad Sci U S A 107:4585-9
Kennedy, Ryan; Lladser, Manuel E; Wu, Zhiyuan et al. (2010) Natural and artificial RNAs occupy the same restricted region of sequence space. RNA 16:280-9
Chumachenko, N V; Novikov, Y; Yarus, M (2009) Rapid and simple ribozymic aminoacylation using three conserved nucleotides. J Am Chem Soc 131:5257-63

Showing the most recent 10 out of 34 publications