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Delino, Nicole S; Aoki, Manabu; Hayashi, Hironori et al. (2018) GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants. Antimicrob Agents Chemother 62:
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Ghosh, Arun K; Sarkar, Anindya; Brindisi, Margherita (2018) The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses. Org Biomol Chem 16:2006-2027
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Ghosh, Arun K; Simpson, Hannah M; Veitschegger, Anne M (2018) Enantioselective total synthesis of decytospolide A and decytospolide B using an Achmatowicz reaction. Org Biomol Chem 16:5979-5986
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Wong-Sam, Andres; Wang, Yuan-Fang; Zhang, Ying et al. (2018) Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease. ACS Omega 3:12132-12140
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Ghosh, Arun K; Ghosh, Koena; Brindisi, Margherita et al. (2018) Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand. Bioorg Med Chem Lett 28:2605-2610
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Ghosh, Arun K; R Nyalapatla, Prasanth; Kovela, Satish et al. (2018) Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis. J Med Chem 61:4561-4577
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Ghosh, Arun K; Jadhav, Ravindra D; Simpson, Hannah et al. (2018) Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands. Eur J Med Chem 160:171-182
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Ghosh, Arun K; Rao, Kalapala Venkateswara; Nyalapatla, Prasanth R et al. (2018) Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants. ChemMedChem 13:803-815
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Ghosh, Arun K; Brindisi, Margherita; Yen, Yu-Chen et al. (2017) Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands. Bioorg Med Chem Lett 27:2432-2438
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Ghosh, Arun K; Sarkar, Anindya (2017) An enantioselective enzymatic desymmetrization route to hexahydro-4H-furopyranol, a high-affinity ligand for HIV-1 protease inhibitors. Tetrahedron Lett 58:3230-3233
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Showing the most recent 10 out of 132 publications
