Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL040992-10
Application #
2649475
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1988-07-01
Project End
1998-07-31
Budget Start
1997-07-01
Budget End
1998-07-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Physiology
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Ginnan, Roman; Guikema, Benjamin J; Halligan, Katharine E et al. (2008) Regulation of smooth muscle by inducible nitric oxide synthase and NADPH oxidase in vascular proliferative diseases. Free Radic Biol Med 44:1232-45
Ginnan, Roman; Guikema, Benjamin J; Singer, Harold A et al. (2006) PKC-delta mediates activation of ERK1/2 and induction of iNOS by IL-1beta in vascular smooth muscle cells. Am J Physiol Cell Physiol 290:C1583-91
Ginnan, Roman; Singer, Harold A (2005) PKC-delta-dependent pathways contribute to PDGF-stimulated ERK1/2 activation in vascular smooth muscle. Am J Physiol Cell Physiol 288:C1193-201
Ginnan, Roman; Pfleiderer, Paul J; Pumiglia, Kevin et al. (2004) PKC-delta and CaMKII-delta 2 mediate ATP-dependent activation of ERK1/2 in vascular smooth muscle. Am J Physiol Cell Physiol 286:C1281-9
Ginnan, Roman; Singer, Harold A (2002) CaM kinase II-dependent activation of tyrosine kinases and ERK1/2 in vascular smooth muscle. Am J Physiol Cell Physiol 282:C754-61
Rokolya, A; Walsh, M P; Singer, H A et al. (1998) Protein kinase C--catalyzed calponin phosphorylation in swine carotid arterial homogenate. J Cell Physiol 176:545-52
Bhat, G J; Abraham, S T; Singer, H A et al. (1997) Alpha-thrombin stimulates sis-inducing factor-A DNA binding activity in rat aortic smooth muscle cells. Hypertension 29:356-60
Busuttil, S J; Morehouse, D L; Youkey, J R et al. (1996) Antisense suppresssion of protein kinase C-alpha and -delta in vascular smooth muscle. J Surg Res 63:137-42
Schorb, W; Conrad, K M; Singer, H A et al. (1995) Angiotensin II is a potent stimulator of MAP-kinase activity in neonatal rat cardiac fibroblasts. J Mol Cell Cardiol 27:1151-60
Booz, G W; Taher, M M; Baker, K M et al. (1994) Angiotensin II induces phosphatidic acid formation in neonatal rat cardiac fibroblasts: evaluation of the roles of phospholipases C and D. Mol Cell Biochem 141:135-43

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