We propose to conduct a study to explore specific oral health outcomes in relation to new generation immunosuppressants in a population of pediatric renal transplant recipients (RTRs) and liver transplant recipients (LTRs) at UCSF. Oral health outcomes of interest include mucosal diseases (e.g., candidiasis, hairy leukoplakia, ulcers, warts, lip carcinoma, non-Hodgkin's lymphoma, and Kaposi's sarcoma (KS), gingival enlargement (GE), and dental needs. The principal investigator of the proposed study is a recipient of a K23 award that bears as its central theme the study of oral health outcomes among adult RTRs. Dr. Shiboski also received a small amount of pilot funds to study utilization of dental care among medically compromised children. As part of this pilot project she has been recruiting, and administering oral health questionnaires to pediatric RTRs and LTRs at UCSF. ? ? Taking advantage of this developing research infrastructure, the goal of the present application is to request funds to conduct a prospective study among pediatric RTRs and LTRs, exploring specific oral health outcomes by following these children at 6-months intervals over a 2-year period. ? ? The Specific Aims of the proposed study among pediatric RTRs and LTRs are: ? ? a. To estimate the prevalence and incidence of oral mucosal diseases and GE in relation to new immunosuppressive drug regimens, type of transplant, and time since transplant surgery; ? b. To estimate the prevalence of unmet dental need in relation to socio-demographic variables and time since transplant surgery; ? c. To collect preliminary data on any potential association between unmet dental needs (e.g., advanced caries, chronic gingival inflammation associated with GE) and history of acute graft rejection episode(s). ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Small Research Grants (R03)
Project #
1R03DE014939-01A1
Application #
6677961
Study Section
NIDCR Special Grants Review Committee (DSR)
Program Officer
Canto, Maria Teresa
Project Start
2003-08-01
Project End
2005-05-31
Budget Start
2003-08-01
Budget End
2004-05-31
Support Year
1
Fiscal Year
2003
Total Cost
$75,750
Indirect Cost
Name
University of California San Francisco
Department
Anatomy/Cell Biology
Type
Schools of Dentistry
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Brown, Carolyn; Krishnan, Sumathi; Hursh, Kevin et al. (2012) Dental disease prevalence among methamphetamine and heroin users in an urban setting: a pilot study. J Am Dent Assoc 143:992-1001
Shiboski, Caroline H; Kawada, Phyllis; Golinveaux, Megan et al. (2009) Oral disease burden and utilization of dental care patterns among pediatric solid organ transplant recipients. J Public Health Dent 69:48-55